Analyses of single nucleotide polymorphisms in selected nutrient-sensitive genes in weight-regain prevention: the DIOGENES study

被引：31

作者：

Larsen, Lesli H. ^{[1
]}

Angquist, Lars ^{[2
]}

Vimaleswaran, Karani S. ^{[3
]}

Hager, Jorg ^{[4
]}

Viguerie, Nathalie ^{[5
]}

Loos, Ruth J. F. ^{[3
]}

Handjieva-Darlenska, Teodora ^{[6
]}

Jebb, Susan A. ^{[7
]}

Kunesova, Marie ^{[8
]}

Larsen, Thomas M.

Alfredo Martinez, J. ^{[9
]}

Papadaki, Angeliki ^{[10
]}

Pfeiffer, Andreas F. H. ^{[11
]}

van Baak, Marleen A. ^{[12
]}

Sorensen, Thorkild I. A. ^{[2
]}

Holst, Claus ^{[2
]}

Langin, Dominique ^{[5
]}

Astrup, Arne

Saris, Wim H. M. ^{[12
]}

机构：

[1] Univ Copenhagen, Dept Human Nutr, Fac Life Sci, LIFE, DK-1958 Frederiksberg C, Denmark

[2] Copenhagen Univ Hosp, Inst Prevent Med, Copenhagen, Denmark

[3] Addenbrookes Hosp, MRC Epidemiol Unit, Inst Metab Sci, Cambridge, England

[4] CEA Genom Inst Ctr Natl Genotypage, Evry, France

[5] Univ Toulouse, INSERM, Obes Res Lab, Metab & Cardiovasc Med Inst,U1048, Toulouse, France

[6] Natl Transport Hosp, Dept Nutr Dietet & Metab Dis, Sofia, Bulgaria

[7] MRC Human Nutr Res, Elsie Widdowson Lab, Cambridge, England

[8] Obes Management Ctr, Inst Endocrinol, Prague, Czech Republic

[9] Univ Navarra, Dept Physiol & Nutr, E-31080 Pamplona, Spain

[10] Univ Crete, Dept Social Med, Rethimnon, Crete, Greece

[11] Charite, Dept Endocrinol Diabet & Nutr, D-13353 Berlin, Germany

[12] Maastricht Univ, Med Ctr, Dept Human Biol, NUTRIM Sch Nutr Toxicol & Metab, Maastricht, Netherlands

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2012年 / 95卷 / 05期

关键词：

BEHAVIOR INTERACTIONS; GLYCEMIC INDEX; PROTEIN; OBESITY; DIETS;

D O I：

10.3945/ajcn.111.016543

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Differences in the interindividual response to dietary intervention could be modified by genetic variation in nutrient-sensitive genes. Objective: This study examined single nucleotide polymorphisms (SNPs) in presumed nutrient-sensitive candidate genes for obesity and obesity-related diseases for main and dietary interaction effects on weight, waist circumference, and fat mass regain over 6 mo. Design: In total, 742 participants who had lost >= 8% of their initial body weight were randomly assigned to follow 1 of 5 different ad libitum diets with different glycemic indexes and contents of dietary protein. The SNP main and SNP-diet interaction effects were analyzed by using linear regression models, corrected for multiple testing by using Bonferroni correction and evaluated by using quantile-quantile (Q-Q) plots. Results: After correction for multiple testing, none of the SNPs were significantly associated with weight, waist circumference, or fat mass regain. Q-Q plots showed that ALOX5AP rs4769873 showed a higher observed than predicted P value for the association with less waist circumference regain over 6 mo (-3.1 cm/allele; 95% CI: -4.6, -1.6; P/Bonferroni-corrected P = 0.000039/0.076), independently of diet. Additional associations were identified by using Q-Q plots for SNPs in ALOX5AP, TNF, and KCNJ11 for main effects; in LPL and TUB for glycemic index interaction effects on waist circumference regain; in GHRL, CCK, MLXIPL, and LEPR on weight; in PPARC1A, PCK2, ALOX5AP, PYY, and ADRB3 on waist circumference; and in PPARD, FABP1, PLAUR, and LPIN1 on fat mass regain for dietary protein interaction. Conclusion: The observed effects of SNP-diet interactions on weight, waist, and fat mass regain suggest that genetic variation in nutrient-sensitive genes can modify the response to diet. This trial was registered at clinicaltrials.gov as NCT00390637. Am J Clin Nutr 2012;95:1254-60.

引用

页码：1254 / 1260

页数：7

共 22 条

[1] Energy-restricted diets based on a distinct food selection affecting the glycemic index induce different weight loss and oxidative response [J].

Abete, Itziar ;

Parra, Dolores ;

Martinez, J. Alfredo .

CLINICAL NUTRITION, 2008, 27 (04) :545-551

[2] Obesity and the metabolic syndrome: role of different dietary macronutrient distribution patterns and specific nutritional components on weight loss and maintenance [J].

Abete, Itziar ;

Astrup, Arne ;

Alfredo Martinez, J. ;

Thorsdottir, Inga ;

Zulet, Maria A. .

NUTRITION REVIEWS, 2010, 68 (04) :214-231

[3] Haploview: analysis and visualization of LD and haplotype maps [J].

Barrett, JC ;

Fry, B ;

Maller, J ;

Daly, MJ .

BIOINFORMATICS, 2005, 21 (02) :263-265

[4]

Bocher V, 2002, ANN NY ACAD SCI, V967, P7

[5] Studying Gene-Behavior Interactions: Summary of Recommendations [J].

Bouchard, Claude ;

Agurs-Collins, Tanya .

OBESITY, 2008, 16 :S95-S96

[6] Implications of Gene-Behavior Interactions: Prevention and Intervention for Obesity [J].

Bray, Molly S. .

OBESITY, 2008, 16 :S72-S78

[7]

de Bakker PI, 2009, COLD SPRING HARB PRO, V2009

[8] Genetic variants influencing effectiveness of weight loss strategies [J].

Deram, Sophie ;

Villares, Sandra M. F. .

ARQUIVOS BRASILEIROS DE ENDOCRINOLOGIA E METABOLOGIA, 2009, 53 (02) :129-138

[9] Genetic Polymorphisms in the Hypothalamic Pathway in Relation to Subsequent Weight Change - The DiOGenes Study [J].

Du, Huaidong ;

Vimaleswaran, Karani S. ;

Angquist, Lars ;

Hansen, Rikke D. ;

van der A, Daphne L. ;

Holst, Claus ;

Tjonneland, Anne ;

Overvad, Kim ;

Jakobsen, Marianne Uhre ;

Boeing, Heiner ;

Meidtner, Karina ;

Palli, Domenico ;

Masala, Giovanna ;

Bouatia-Naji, Nabila ;

Saris, Wim H. M. ;

Feskens, Edith J. M. ;

Wareham, Nicolas J. ;

Sorensen, Thorkild I. A. ;

Loos, Ruth J. F. .

PLOS ONE, 2011, 6 (02)

[10] What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases [J].

Evans, Jilly F. ;

Ferguson, Andrew D. ;

Mosley, Ralph T. ;

Hutchinson, John H. .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2008, 29 (02) :72-78

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