Effect of Sophora Flavescens Alkaloids on the Proliferation and Migration of Vascular Smooth Muscle Cells and Endothelial Cells

被引：0

作者：

Wang, Gui-Xue ^{[1
]}

Chen, Huo-Lin ^{[1
]}

Jiang, Hong-Yan ^{[1
,2
]}

Yin, Tie-Ying ^{[1
]}

Wu, Ling-Yan ^{[1
]}

机构：

[1] Chongqing Univ, Bioengn Coll, Chongqing Engn Lab Vasc Implants, Key Lab Biorheol Sci & Technol,Minist Educ, Chongqing 400044, Peoples R China

[2] Chongqing Med & Pharmaceut Coll, Chongqing 400030, Peoples R China

来源：

JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING | 2012年 / 32卷 / 03期

基金：

中国国家自然科学基金;

关键词：

Sophora flavescens alkaloid (matrine); Vascular smooth muscle cells (VSMCs); Endothelial cells; Proliferation; Migration; PROTEIN-KINASE-A; IN-VITRO; STENT RESTENOSIS; KAPPA-B; ADHESION; MATRINE; PHOSPHORYLATION; DIFFERENTIATION; ERA;

D O I：

10.5405/jmbe.872

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Colorimetric analysis is used to investigate the effect of matrine (a Sophora flavescens alkaloid) concentration on the proliferation and migration of vascular smooth muscle cells (VSMCs) and vascular endothelial cells (VECs) with a flow chamber system under various physiological shear flow rates. After treatment with matrine at concentrations of 0, 0.625, 1.25, 2.5, and 5 mg/ml for 24 hours, the inhibition rates of VSMC proliferation are 0%, 23.62% (+/- 0.44), 49.37% (+/-0.71), 75.43% (+/- 0.68), and 83.81% (+/- 1.09), respectively, and those of WC proliferation are 0%, 7.50% (+/- 1.88), 17.47% (+/- 2.50), 26.59% (+/- 5.90), and 34.44% (+/- 0.76), respectively. Statistical analysis indicates that matrine inhibits the proliferation of VSMCs and VECs in a concentration-dependent manner. Matrine in concentrations of 0.625 mg/ml to 5.0 ing/ml can significantly inhibit the migration of VSMCs and VECs under physiological shear flow (P < 0.05).

引用

页码：195 / 199

页数：5

共 19 条

[1] Drug-eluting stents: new era and new concerns [J].