Enzyme-catalyzed resolution of aromatic ring fused cyclic tertiary alcohols

被引：25
|
作者：
Ozdemirhan, Devrim [1 ]
Sezer, Serdar [2 ]
Sonmez, Yasemin [1 ]
机构：
[1] Abant Izzet Baysal Univ, Dept Chem, TR-14280 Bolu, Turkey
[2] Middle E Tech Univ, Dept Chem, TR-06531 Ankara, Turkey
来源：
TETRAHEDRON-ASYMMETRY | 2008年 / 19卷 / 23期
关键词：
D O I：
10.1016/j.tetasy.2008.12.002
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
An efficient chemoenzymatic route for the synthesis of optically active aromatic ring fused cyclic tertiary alcohols (S)-(-)-1-methyl-1,2,3,4-tetrahydronaphthalen-1-ol (-)-1b and (S)-(+)-1-methyl-2,3-dihydro-1H-inden-1-ol (+)-1a has been developed. Different lipases have been tested in the transesterification of these tertiary alcohols; CAL-A (Candida antarctica Lipase A) was found to be the best biocatalyst for 1b and CAL-A-CLEA (Lipase A, C. antarctica, cross-linked enzyme aggregate) for la, obtained with ee values of 20% and 45%, respectively, and the corresponding esters 2b and 2a with the ee values of 99% and 71%, respectively. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2717 / 2720
页数：4
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