Functional Brain Mapping at 9.4T Using a New MRI-Compatible Electrode Chronically Implanted in Rats

被引：32

作者：

Dunn, Jeff F. ^{[1
]}

Tuor, Ursula I. ^{[2
]}

Kmech, Jonn

Young, Nicole A. ^{[3
]}

Henderson, Amy K. ^{[3
]}

Jackson, Jesse C. ^{[3
]}

Valentine, Pamela A. ^{[3
]}

Teskey, G. Campbell ^{[3
]}

机构：

[1] Univ Calgary, Dept Radiol, Fac Med, Hotchkiss Brain Inst,Expt Imaging Ctr, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Hotchkiss Brain Inst, Natl Res Council, Inst Biodiagnost W, Calgary, AB T2N 4N1, Canada

[3] Univ Calgary, Hotchkiss Brain Inst, Dept Psychol, Behav Neurosci Res Grp, Calgary, AB T2N 4N1, Canada

来源：

MAGNETIC RESONANCE IN MEDICINE | 2009年 / 61卷 / 01期

基金：

加拿大自然科学与工程研究理事会; 美国国家卫生研究院; 加拿大健康研究院;

关键词：

MRI; fMRI; epilepsy; electrode; brain stimulation; DIRECT THALAMIC-STIMULATION; MOTOR MAP EXPANSION; ELECTRICAL MICROSTIMULATION; BOLD RESPONSE; FMRI; SIGNAL; INDUCTION; CORTEX; LEVEL; MODEL;

D O I：

10.1002/mrm.21803

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

There is a need for acute and chronic stimulation of the brain within the MRI for studies of epilepsy, as well as deep brain stimulation for movement and behavioral disorders. This work describes the production and characteristics of carbon fiber-based electrodes for acute and chronic stimulation in the brain. Increasing MRI field strengths are making it increasingly difficult to introduce foreign objects without a susceptibility artifact. We describe the production of, and the characteristics of carbon fiber-based electrodes. These are biocompatible and can be implanted for chronic studies. We show the use of these electrodes at 9.4T for studying functional activation. Data are presented showing regional connectivity. Activation not only occurs near the electrode, but at sites distant and often contralateral to the electrode. In addition, there were sites showing strong negative activation to stimulation both with direct stimulation and during a kindling-associated seizure. Magn Reson Med 61:222-228, 2009. (C) 2008 Wiley-Liss, Inc.

引用

页码：222 / 228

页数：7

共 22 条

[1]

[Anonymous], 1992, Brain Maps: Structure of the Rat Brain

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