Point-of-Care Diagnosis and Prognostication of Cryptococcal Meningitis With the Cryptococcal Antigen Lateral Flow Assay on Cerebrospinal Fluid

被引：93

作者：

Kabanda, Taseera ^{[1
]}

Siedner, Mark J. ^{[2
]}

Klausner, Jeffrey D. ^{[3
,4
]}

Muzoora, Conrad ^{[1
]}

Boulware, David R. ^{[5
]}

机构：

[1] Mbarara Univ Sci & Technol, Fac Med, Dept Med, Kampala, Uganda

[2] Harvard Univ, Sch Med, Dept Med, Massachusetts Gen Hosp, Boston, MA USA

[3] Univ Calif Los Angeles, Dept Med, Ctr World Hlth, Los Angeles, CA 90024 USA

[4] Univ Calif Los Angeles, Div Infect Dis, Los Angeles, CA USA

[5] Univ Minnesota, Dept Med, Div Infect Dis & Int Med, Minneapolis, MN 55455 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2014年 / 58卷 / 01期

基金：

英国医学研究理事会;

关键词：

HIV; cryptococcal meningitis; diagnosis; point-of-care; sub-Saharan Africa; AMPHOTERICIN-B; CLEARANCE; BURDEN;

D O I：

10.1093/cid/cit641

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cryptococcal antigen (CRAG) lateral flow assay (LFA) had 100% sensitivity and specificity on cerebrospinal fluid samples. Pretreatment LFA titers correlated with quantitative cultures (R-2 = 0.7) and predicted 2- and 10-week mortality. The CRAG LFA is an accurate diagnostic assay for CSF and should be considered for point-of-care diagnosis of cryptococcal meningitis.

引用

收藏

页码：113 / 116

页数：4

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