In Vitro Activity of Fosfomycin against Escherichia coli Isolated from Patients with Urinary Tract Infections in Canada as Part of the CANWARD Surveillance Study

被引：41

作者：

Karlowsky, James A. ^{[1
,2
]}

Denisuik, Andrew J. ^{[2
]}

Lagace-Wiens, Philippe R. S. ^{[1
,2
]}

Adam, Heather J. ^{[1
,2
]}

Baxter, Melanie R. ^{[2
]}

Hoban, Daryl J. ^{[1
,2
]}

Zhanel, George G. ^{[2
]}

机构：

[1] Diagnost Serv Manitoba, Winnipeg, MB, Canada

[2] Univ Manitoba, Fac Med, Dept Med Microbiol & Infect Dis, Winnipeg, MB, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 02期

关键词：

SPECTRUM BETA-LACTAMASE; ANTIMICROBIAL RESISTANCE; MOLECULAR EPIDEMIOLOGY; KLEBSIELLA-PNEUMONIAE; PATHOGENS; HOSPITALS;

D O I：

10.1128/AAC.02399-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We tested 868 urinary isolates of Escherichia coli collected from 2010 to 2013 as part of the Canadian national surveillance study CANWARD against fosfomycin by using the Clinical and Laboratory Standards Institute (CLSI) agar dilution method with MIC interpretation in accordance with the CLSI M100-S23 (2013) criteria. The concentrations of fosfomycin inhibiting 50 and 90% of the isolates were <= 1 and 4 mu g/ml; 99.4% of the isolates were susceptible to fosfomycin.

引用

页码：1252 / 1256

页数：5

共 15 条

[1] Oral Treatment Options for Ambulatory Patients with Urinary Tract Infections Caused by Extended-Spectrum-β-Lactamase-Producing Escherichia coli [J].

Auer, Simon ;

Wojna, Alexandra ;

Hell, Markus .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (09) :4006-4008

[2]

Clinical and Laboratory Standards Institute, 2012, M07A9 CLIN LAB STAND, V32

[3]

Clinical Laboratory Standards Institute, 2013, M100S23 CLSI

[4] Molecular epidemiology of extended-spectrum β-lactamase-, AmpC β-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11 [J].

Denisuik, Andrew J. ;

Lagace-Wiens, Philippe R. S. ;

Pitout, Johann D. ;

Mulvey, Michael R. ;

Simner, Patricia J. ;

Tailor, Franil ;

Karlowsky, James A. ;

Hoban, Daryl J. ;

Adam, Heather J. ;

Zhanel, George G. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2013, 68 :i57-i65

[5]

Gupta K, 2011, CLIN INFECT DIS, V52, pE103, DOI [10.1093/cid/ciq257, 10.1093/cid/cir102]

[6] Prevalence and molecular epidemiology of plasmid-mediated fosfomycin resistance genes among blood and urinary Escherichia coli isolates [J].

Ho, Pak-Leung ;

Chan, Jane ;

Lo, Wai-U ;

Lai, Eileen L. ;

Cheung, Yuk-Yam ;

Lau, Terrence C. K. ;

Chow, Kin-Hung .

JOURNAL OF MEDICAL MICROBIOLOGY, 2013, 62 :1707-1713

[7] Fosfomycin: evaluation of the published evidence on the emergence of antimicrobial resistance in Gram-negative pathogens [J].

Karageorgopoulos, Drosos E. ;

Wang, Rui ;

Yu, Xu-hong ;

Falagas, Matthew E. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2012, 67 (02) :255-268

[8] Antimicrobial Resistance in Urinary Tract Pathogens in Canada from 2007 to 2009: CANWARD Surveillance Study [J].

Karlowsky, James A. ;

Lagace-Wiens, Philippe R. S. ;

Simner, Patricia J. ;

DeCorby, Melanie R. ;

Adam, Heather J. ;

Walkty, Andrew ;

Hoban, Daryl J. ;

Zhanel, George G. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (07) :3169-3175

[9] Antimicrobial susceptibilities of urinary extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella pneumoniae to fosfomycin and nitrofurantoin in teaching hospital in Taiwan [J].

Liu, Hsin-Yi ;

Lin, Hsiu-Chen ;

Lin, Yi-Chun ;

Yu, Shao-hua ;

Wu, Wui-Hsiu ;

Lee, Yuarn-Jang .

JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION, 2011, 44 (05) :364-368

[10] Experience with Fosfomycin for Treatment of Urinary Tract Infections Due to Multidrug-Resistant Organisms [J].

Neuner, Elizabeth A. ;

Sekeres, Jennifer ;

Hall, Gerri S. ;

van Duin, David .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2012, 56 (11) :5744-5748

← 1 2 →