Outcomes of Kawasaki disease with giant coronary aneurysms: a single-centre study in southwest China

被引:9
作者
Yuan, Piaoliu [1 ]
Su, Danyan [1 ]
Mandal, Krishna D. [1 ]
Qin, Suyuan [1 ]
Zhao, Na [1 ]
Pang, Yusheng [1 ]
机构
[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Pediat, 22 Shuangyong Rd, Nanning 530021, Guangxi Autonom, Peoples R China
关键词
Kawasaki disease; giant coronary aneurysms; outcome; follow-up; myocardial infarction; LONG-TERM MANAGEMENT; HEALTH-PROFESSIONALS; EPIDEMIOLOGY; STATEMENT; DIAGNOSIS; SECONDARY; SAFETY; YOUNG;
D O I
10.1017/S1047951120001134
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Giant coronary aneurysms are the most severe complications of Kawasaki disease. There are few reports of outcomes from China. Most previous studies were based only on absolute aneurysmal dimensions. The aim of the present study was to catalog the outcomes of Kawasaki disease with giant coronary aneurysms in southwest China based on absolute dimensions and the z-score adjusted for body surface area. Methods and results: All patients diagnosed with giant coronary aneurysms (z-score >= 10 or absolute dimension >= 8 mm) between December, 2002 and December, 2018 were included. We retrospectively analysed patient characteristics and clinical data from 38 patients with giant coronary aneurysms. Over a median follow-up period of 30.5 months (range from 1.7 months to 22.3 years), including patients in chronic phase who had been diagnosed prior to 2002, eight patients had myocardial infarction, including two deaths and one patient with coronary artery bypass grafting. The 1-, 2-, and 5-year event-free rates were 0.63, 0.63, and 0.53 for thrombosis, respectively, and 0.86, 0.81, and 0.81 for major adverse cardiac events, respectively. The 1-, 2-, and 5-year regression-free rates were 0.94, 0.85, and 0.67, respectively. A total of 73.7% of patients remained active. Conclusion: In the early stages of Kawasaki disease, patients with giant coronary aneurysms often experience major cardiovascular events; however, they are also likely to have normalisation of the coronary internal luminal diameter. With long-term anticoagulation, close cardiologic monitoring, and prompt thrombolytic therapy, most patients can achieve disease-free periods.
引用
收藏
页码:834 / 839
页数:6
相关论文
共 21 条
  • [1] Sequelae of Kawasaki disease in adolescents and young adults
    Burns, JC
    Shike, H
    Gordon, JB
    Malhotra, A
    Schoenwetter, M
    Kawasaki, T
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 28 (01) : 253 - 257
  • [2] Regression and Complications of z-score-Based Giant Aneurysms in a Dutch Cohort of Kawasaki Disease Patients
    Dietz, S. M.
    Kuipers, I. M.
    Koole, J. C. D.
    Breur, J. M. P. J.
    Fejzic, Z.
    Frerich, S.
    Dalinghaus, M.
    Roest, A. A. W.
    Hutten, B. A.
    Kuijpers, T. W.
    [J]. PEDIATRIC CARDIOLOGY, 2017, 38 (04) : 833 - 839
  • [3] Coronary Artery Aneurysms in Kawasaki Disease: Risk Factors for Progressive Disease and Adverse Cardiac Events in the US Population
    Friedman, Kevin G.
    Gauvreau, Kimberly
    Hamaoka-Okamoto, Akiko
    Tang, Alexander
    Berry, Erika
    Tremoulet, Adriana H.
    Mahavadi, Vidya S.
    Baker, Annette
    deFerranti, Sarah D.
    Fulton, David R.
    Burns, Jane C.
    Newburger, Jane W.
    [J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2016, 5 (09):
  • [4] Nationwide Survey of Patients With Giant Coronary Aneurysm Secondary to Kawasaki Disease 1999-2010 in Japan
    Fukazawa, Ryuji
    Kobayashi, Tohru
    Mikami, Masashi
    Saji, Tsutomu
    Hamaoka, Kenji
    Kato, Hitoshi
    Suzuki, Hiroyuki
    Tsuda, Etsuko
    Ayusawa, Mamoru
    Miura, Masaru
    Ebata, Ryota
    Kobayashi, Tomio
    Yashiro, Mayumi
    Ogawa, Shunichi
    [J]. CIRCULATION JOURNAL, 2018, 82 (01) : 239 - +
  • [5] Giant coronary artery aneurysms complicating Kawasaki disease in Mexican children
    Garrido-Garcia, Luis M.
    Moran-Villasenor, Edna
    Yamazaki-Nakashimada, Marco A.
    Cravioto, Patricia
    Galvan, Fernando
    [J]. CARDIOLOGY IN THE YOUNG, 2018, 28 (03) : 386 - 390
  • [6] Safety and outcomes of thrombolysis with tissue plasminogen activator for treatment of intravascular thrombosis in children
    Gupta, AA
    Leaker, M
    Andrew, M
    Massicotte, P
    Liu, L
    Benson, LN
    McCrindle, BW
    [J]. JOURNAL OF PEDIATRICS, 2001, 139 (05) : 682 - 688
  • [7] Long-term Cardiovascular Outcomes in Survivors of Kawasaki Disease
    Holve, Taylor J.
    Patel, Ajay
    Chau, Quyen
    Marks, Amy R.
    Meadows, Alison
    Zaroff, Jonathan G.
    [J]. PEDIATRICS, 2014, 133 (02) : E305 - E311
  • [8] Long term consequences of regressed coronary aneurysms after Kawasaki disease: vascular wall morphology and function
    Iemura, M
    Ishii, M
    Sugimura, T
    Akagi, T
    Kato, H
    [J]. HEART, 2000, 83 (03) : 307 - 311
  • [9] A New Z Score Curve of the Coronary Arterial Internal Diameter Using the Lambda-Mu-Sigma Method in a Pediatric Population
    Kobayashi, Tohru
    Fuse, Shigeto
    Sakamoto, Naoko
    Mikami, Masashi
    Ogawa, Shunichi
    Hamaoka, Kenji
    Arakaki, Yoshio
    Nakamura, Tsuneyuki
    Nagasawa, Hiroyuki
    Kato, Taichi
    Jibiki, Toshiaki
    Iwashima, Satoru
    Yamakawa, Masaru
    Ohkubo, Takashi
    Shimoyama, Shinya
    Aso, Kentaro
    Sato, Seiichi
    Saji, Tsutomu
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY, 2016, 29 (08) : 794 - +
  • [10] Acute and late coronary outcomes in 1073 patients with Kawasaki disease with and without intravenous γ-immunoglobulin therapy
    Lin, Ming-Tai
    Sun, Li-Chuan
    Wu, En-Ting
    Wang, Jou-Kou
    Lue, Hung-Chi
    Wu, Mei-Hwan
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD, 2015, 100 (06) : 542 - 547