Patient-Specific Stem Cells and Cardiovascular Drug Discovery

被引：30
作者：
Mordwinkin, Nicholas M. [1 ,2 ]
Lee, Andrew S. [1 ,2 ]
Wu, Joseph C. [1 ,2 ]
机构：
[1] Stanford Univ, Stanford Cardiovasc Inst, Dept Med, Div Cardiol, Stanford, CA 94305 USA
[2] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Stanford, CA 94305 USA
来源：
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 2013年 / 310卷 / 19期
关键词：
D O I：
10.1001/jama.2013.282409
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：2039 / 2040
页数：2
相关论文
共 9 条
[1]   Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment [J].
Abassi, Yama A. ;
Xi, Biao ;
Li, Nan ;
Ouyang, Wei ;
Seiler, Alexander ;
Watzele, Manfred ;
Kettenhofen, Ralf ;
Bohlen, Heribert ;
Ehlich, Andreas ;
Kolossov, Eugen ;
Wang, Xiaobo ;
Xu, Xiao .
BRITISH JOURNAL OF PHARMACOLOGY, 2012, 165 (05) :1424-1441
[2]   Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming [J].
Burridge, Paul W. ;
Keller, Gordon ;
Gold, Joseph D. ;
Wu, Joseph C. .
CELL STEM CELL, 2012, 10 (01) :16-28
[3]   Drug attrition during pre-clinical and clinical development: Understanding and managing drug-induced cardiotoxicity [J].
Ferri, Nicola ;
Siegl, Peter ;
Corsini, Alberto ;
Herrmann, Joerg ;
Lerman, Amir ;
Benghozi, Renee .
PHARMACOLOGY & THERAPEUTICS, 2013, 138 (03) :470-484
[4]   Drug Screening Using a Library of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Reveals Disease-Specific Patterns of Cardiotoxicity [J].
Liang, Ping ;
Lan, Feng ;
Lee, Andrew S. ;
Gong, Tingyu ;
Sanchez-Freire, Veronica ;
Wang, Yongming ;
Diecke, Sebastian ;
Sallam, Karim ;
Knowles, Joshua W. ;
Wang, Paul J. ;
Nguyen, Patricia K. ;
Bers, Donald M. ;
Robbins, Robert C. ;
Wu, Joseph C. .
CIRCULATION, 2013, 127 (16) :1677-+
[5]   Drugs in Search of Diseases [J].
Paul, Steven M. ;
Lewis-Hall, Freda .
SCIENCE TRANSLATIONAL MEDICINE, 2013, 5 (186)
[6]   How to improve R&D productivity: the pharmaceutical industry's grand challenge [J].
Paul, Steven M. ;
Mytelka, Daniel S. ;
Dunwiddie, Christopher T. ;
Persinger, Charles C. ;
Munos, Bernard H. ;
Lindborg, Stacy R. ;
Schacht, Aaron L. .
NATURE REVIEWS DRUG DISCOVERY, 2010, 9 (03) :203-214
[7]   Diagnosing the decline in pharmaceutical R&D efficiency [J].
Scannell, Jack W. ;
Blanckley, Alex ;
Boldon, Helen ;
Warrington, Brian .
NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (03) :191-200
[8]   Induction of pluripotent stem cells from adult human fibroblasts by defined factors [J].
Takahashi, Kazutoshi ;
Tanabe, Koji ;
Ohnuki, Mari ;
Narita, Megumi ;
Ichisaka, Tomoko ;
Tomoda, Kiichiro ;
Yamanaka, Shinya .
CELL, 2007, 131 (05) :861-872
[9]   Combination of isosorbide dinitrate and hydralazine in blacks with heart failure [J].
Taylor, AL ;
Ziesche, S ;
Yancy, C ;
Carson, P ;
D'Agostino, R ;
Ferdinand, K ;
Taylor, M ;
Adams, K ;
Sabolinski, M ;
Worcel, M ;
Cohn, JN .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (20) :2049-2057
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