New cassaine diterpenoid Amides with cytotoxic activities from the bark of Erythrophleum fordii

被引：38
作者：
Qu, J
Hu, YC
Yu, SS
Chen, XG
Li, Y
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing, Peoples R China
[3] Peking Union Med Coll, Beijing, Peoples R China
来源：
PLANTA MEDICA | 2006年 / 72卷 / 05期
关键词：
Erythrophleum fordii; leguminosae; cassaine diterpenoid amides; cytotoxic activities;
D O I：
10.1055/s-2005-916264
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A phytochemical investigation of the bark of Erythrophleum fordii led to six new cassaine diterpenoid amides (2, 4 - 8), together with two known compounds of the same skeleton, norcassamide (1) and nor-erythrosuamide (3). The structures were mainly established on the basis of 1 D, 2D NMR and HR-MS analysis. The compounds 1, 2, 4, 6 - 8 exhibited selective cytotoxic activities (IC50 values < 10 mu M) against A2780, KB, Bel-7402, BGC-823, MCF-7, HCT-8, Hela, PC-3M, A549 and Ketr3 human cancer cell lines in the MTT test.
引用
收藏
页码：442 / 449
页数：8
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