Human renal cancer stem cells

被引：50

作者：

Bussolati, Benedetta ^{[1
,2
]}

Dekel, Benjamin ^{[3
,4
]}

Azzarone, Bruno ^{[5
]}

Camussi, Giovanni ^{[1
,2
]}

机构：

[1] Univ Turin, Res Ctr Expt Med, Dept Internal Med, I-10124 Turin, Italy

[2] Univ Turin, Ctr Mol Biotechnol, I-10124 Turin, Italy

[3] Tel Aviv Univ, Sackler Sch Med, Pediat Stem Cell Res Inst, IL-69978 Tel Aviv, Israel

[4] Tel Aviv Univ, Sackler Sch Med, Div Pediat Nephrol, Edmond & Lily Safra Childrens Hosp,Sheba Med Ctr, IL-69978 Tel Aviv, Israel

[5] Hop Paul Brousse, INSERM UMR, Villejuif, France

来源：

CANCER LETTERS | 2013年 / 338卷 / 01期

关键词：

Renal cell carcinoma; Wilms' tumor; Tumor stem cells; Differentiation therapy; Angiogenesis; PROGENITOR CELLS; WILMS-TUMOR; IDENTIFICATION; CARCINOMA; DIFFERENTIATION; INTERLEUKIN-15; TUMORIGENESIS; MICROVESICLES; ANGIOGENESIS; POPULATION;

D O I：

10.1016/j.canlet.2012.05.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer stem cells (CSCs), isolated in renal carcinomas, exhibit tumor-initiating capabilities and pluripotency. No specific CSC markers have been identified so far; therefore, their characterization is mainly based on functional studies. As they are resistant to chemo and radio therapy, renal CSCs may have a relevant role in tumor establishment, progression, and recurrence. CSCs were also shown to contribute to intra-tumor vasculogenesis through an endothelial differentiation and to favor the generation of the pre-metastatic niche through the release of exosomes/microvesicles. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：141 / 146

页数：6

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