Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines

被引：48

作者：

Suresh, Narva ^{[1
]}

Nagesh, Hunsur Nagendra ^{[1
]}

Sekhar, Kondapalli Venkata Gowri Chandra ^{[1
]}

Kumar, Anil ^{[2
]}

Shirazi, Amir N. ^{[3
]}

Parang, Keykavous ^{[3
]}

机构：

[1] Birla Inst Technol & Sci Pilani, Dept Chem, Hyderabad 500078, Andhra Pradesh, India

[2] Birla Inst Technol & Sci, Dept Chem, Pilani 333031, Rajasthan, India

[3] Univ Rhode Isl, Coll Pharm, Dept Biomed & Pharmaceut Sci, Kingston, RI 02881 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 23期

关键词：

Ciprofloxacin; Fluoroquinolones Anti-cancer; Anti-proliferative; Substituted piperazines; PROSTATE-CANCER; BIOLOGICAL EVALUATION; CYCLE ARREST; TOPOISOMERASE; GROWTH; INHIBITORS; FLUOROQUINOLONES; DERIVATIVES; CARCINOMA; APOPTOSIS;

D O I：

10.1016/j.bmcl.2013.09.077

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline- 3-carboxylic acid analogues have been synthesized, characterized (1H NMR, 13C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 lM showed comparable potency to doxorubicin (10 lM) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：6292 / 6295

页数：4

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