Do 1,8-naphthyridine sulfonamides possess an inhibitory action against Tet (K) and MsrA efflux pumps in multiresistant Staphylococcus aureus strains?

被引：9

作者：

de Morais Oliveira-Tintino, Cicera Datiane ^{[1
]}

Tintino, Saulo Relison ^{[2
]}

Muniz, Debora Feitosa ^{[2
]}

dos Santos Barbosa, Cristina Rodrigues ^{[2
]}

Silva Pereira, Raimundo Luiz ^{[2
]}

Begnini, Ieda Maria ^{[3
]}

Rebelo, Ricardo Andrade ^{[3
]}

da Silva, Luiz Everson ^{[4
]}

Mireski, Sandro Lucio ^{[3
]}

Nasato, Michele Caroline ^{[3
]}

Lacowicz Krautler, Maria Isabel ^{[3
]}

Pereira, Pedro Silvino ^{[1
]}

Rodrigues Teixeira, Alexandre Magno ^{[5
]}

Alencar de Menezes, Irwin Rose ^{[6
]}

Melo Coutinho, Henrique Douglas ^{[2
]}

da Silva, Teresinha Goncalves ^{[1
]}

机构：

[1] Fed Univ Pernambuco UFPE, Dept Antibiot, Lab Pharmatoxicol Prospecting Bioact Prod, Av Prof Artur Sa S-N,Cidade Univ, BR-54740520 Recife, PE, Brazil

[2] Reg Univ Cariri, Dept Biol Chem, Lab Microbiol & Mol Biol, URCA, Crato, CE, Brazil

[3] Univ Reg Blumenau, Dept Chem, FURB, BR-89030903 Blumenau, SC, Brazil

[4] Univ Fed Parana, Coastal Sect, Postgrad Program Sustainable Terr Dev, Curitiba, Parana, Brazil

[5] Reg Univ Cariri, Dept Biol Chem, Lab Simulat & Mol Spect, URCA, Crato, CE, Brazil

[6] Reg Univ Cariri, Dept Biol Chem, Lab Pharmacol & Mol Chem, URCA, Crato, CE, Brazil

来源：

MICROBIAL PATHOGENESIS | 2020年 / 147卷

关键词：

Antibacterial agent; Bacterial resistance; Efflux pump; Ethidium bromide; Synergism; MULTIDRUG-RESISTANCE; ERYTHROMYCIN RESISTANCE; DRUG-RESISTANCE; EXPRESSION; TETRACYCLINE; MECHANISMS; TRANSPORT; SYSTEM; GENE;

D O I：

10.1016/j.micpath.2020.104268

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naphthyridines represent a class of heterocyclic compounds formed by two condensed aromatic rings. This study aimed to evaluate the antibacterial activity and in vitro inhibition of efflux resistance mechanisms of a series of 1,8-naphthyridine sulfonamides against strains carrying Tet(K) and MsrA efflux pumps. The efflux pump inhibitory capacity was evaluated by analyzing synergistic effects between 1,8-naphthyridine sulfonamides and standard antibiotics, as well as ethidium bromide. The following 1,8-naphthyridines were used: 4-methyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 1); 2,5-Dichloro N (5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 2); 2,3,4-trifluoro-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 7); 3-trifluoromethyl-N-(5-chloro-1,8-naphthyridin-2-yl)-benzenesulfonamide (Naph 9). The 1,8-naphthyridine sulfonamide derivatives possessed a potential Tet(K) and MsrA efflux pump inhibitory action.

引用

页数：5

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