Acute coronary syndromes

被引：0

作者：

Zeymer, U. ^{[1
,2
]}

机构：

[1] Klinikum Ludwigshafen, D-67063 Ludwigshafen, Germany

[2] Inst Herzinfarktforsch Ludwigshafen, Ludwigshafen, Germany

来源：

GEFASSCHIRURGIE | 2013年 / 18卷 / 03期

关键词：

Acute coronary syndrome; Prehospital phase; Platelet inhibitors; Antithrombins; Anticoagulants; ELEVATION MYOCARDIAL-INFARCTION; LOW-DOSE ASPIRIN; PRIMARY ANGIOPLASTY; UNFRACTIONATED HEPARIN; DOUBLE-BLIND; PRIMARY PCI; CLOPIDOGREL; INTERVENTION; ENOXAPARIN; FIBRINOLYSIS;

D O I：

10.1007/s00772-013-1165-1

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Antithrombotic treatment is one of the cornerstones of acute and long-term therapy of patients with acute coronary syndromes (ACS). For this purpose antiplatelet as well as antithrombin agents are used. These drugs can reduce mortality and recurrent ischemic events but may increase bleeding complications. Therefore, simple and easy to use antithrombotic regimens are desirable especially in the prehospital phase to reduce complications associated with overdosing and underdosing. Aspirin is well established for all patients with ACS. In addition an adenosine diphosphate (ADP) receptor blocker should be given in acute therapy and over 12 months after ACS. The value of thrombin inhibitors has been documented mainly for the acute phase. This article summarizes currently available data and recommendations for prehospital antithrombotic therapy in patients with ACS.

引用

页码：231 / 239

页数：9

共 28 条

[1]

[Anonymous], 1988, LANCET, V2, P349

[2] Enoxaparin versus unfractionated heparin with fibrinolysis for ST-elevation myocardial infarction [J].

Antman, EM ;

Morrow, DA ;

McCabe, CH ;

Murphy, SA ;

Ruda, M ;

Sadowski, Z ;

Budaj, A ;

López-Sendón, JL ;

Guneri, S ;

Jiang, F ;

White, HD ;

Fox, KAA ;

Braunwald, E .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (14) :1477-1488

[3] Early glycoprotein IIb-IIIa inhibitors in primary angioplasty (EGYPT) cooperation: an individual patient data meta-analysis [J].

De Luca, G. ;

Gibson, C. M. ;

Bellandi, F. ;

Murphy, S. ;

Maioli, M. ;

Noc, M. ;

Zeymer, U. ;

Dudek, D. ;

Arntz, H.-R. ;

Zorman, S. ;

Gabriel, H. M. ;

Emre, A. ;

Cutlip, D. ;

Biondi-Zoccai, G. ;

Rakowski, T. ;

Gyongyosi, M. ;

Marino, P. ;

Huber, K. ;

van't Hof, A. W. J. .

HEART, 2008, 94 (12) :1548-1558

[4]

Gawaz M, 2012, KARDIOLOGIYA, V6, P195

[5] Early versus Delayed, Provisional Eptifibatide in Acute Coronary Syndromes [J].

Giugliano, Robert P. ;

White, Jennifer A. ;

Bode, Christoph ;

Armstrong, Paul W. ;

Montalescot, Gilles ;

Lewis, Basil S. ;

van't Hof, Arnoud ;

Berdan, Lisa G. ;

Lee, Kerry L. ;

Strony, John T. ;

Hildemann, Steven ;

Veltri, Enrico ;

Van de Werf, Frans ;

Braunwald, Eugene ;

Harrington, Robert A. ;

Califf, Robert M. ;

Newby, L. Kristin .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 360 (21) :2176-2190

[6] Lower-dose heparin with fibrinolysis is associated with lower rates of intracranial hemorrhage [J].

Giugliano, RP ;

McCabe, CH ;

Antman, EM ;

Cannon, CP ;

Van de Werf, F ;

Wilcox, RG ;

Braunwald, E .

AMERICAN HEART JOURNAL, 2001, 141 (05) :742-750

[7] ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation [J].

Hamm, Christian W. ;

Bassand, Jean-Pierre ;

Agewall, Stefan ;

Bax, Jeroen ;

Boersma, Eric ;

Bueno, Hector ;

Caso, Pio ;

Dudek, Dariusz ;

Gielen, Stephan ;

Huber, Kurt ;

Ohman, Magnus ;

Petrie, Mark C. ;

Sonntag, Frank ;

Uva, Miguel Sousa ;

Storey, Robert F. ;

Wijns, William ;

Zahger, Doron .

EUROPEAN HEART JOURNAL, 2011, 32 (23) :2999-3054

[8] Higher efficacy of pre-hospital tirofiban with longer pre-treatment time to primary PCI: protection for the negative impact of time delay [J].

Heestermans, Ton ;

de Boer, Menko-Jan ;

van Werkum, Jochem W. ;

Mosterd, Arend ;

Gosselink, A. T. Marcel ;

Dambrink, Jan-Henk E. ;

van Houwelingen, Gert ;

Koopmans, Petra ;

Hamm, Christian ;

Zijlstra, Felix ;

ten Berg, Jurrien M. ;

van 't Hof, Amoud W. J. .

EUROINTERVENTION, 2011, 7 (04) :442-448

[9]

HIRSH J, 1991, NEW ENGL J MED, V324, P1565

[10] 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update) A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines [J].

Kushner, Frederick G. ;

Hand, Mary ;

Smith, Sidney C., Jr. ;

King, Spencer B., III ;

Anderson, Jeffrey L. ;

Antman, Elliott M. ;

Bailey, Steven R. ;

Bates, Eric R. ;

Blankenship, James C. ;

Casey, Donald E., Jr. ;

Green, Lee A. ;

Hochman, Judith S. ;

Jacobs, Alice K. ;

Krumholz, Harlan M. ;

Morrison, Douglass A. ;

Ornato, Joseph P. ;

Pearle, David L. ;

Peterson, Eric D. ;

Sloan, Michael A. ;

Whitlow, Patrick L. ;

Williams, David O. ;

Kushner, Frederick G. ;

Hand, Mary ;

Antman, Elliott M. ;

Bates, Eric R. ;

Casey, Donald E., Jr. ;

Green, Lee A. ;

Hochman, Judith S. ;

Krumholz, Harlan M. ;

Ornato, Joseph P. ;

Pearle, David L. ;

Sloan, Michael A. ;

Smith, Sidney C. ;

Smith, Sidney C., Jr. ;

King, Spencer B., III ;

Anderson, Jeffrey L. ;

Bailey, Steven R. ;

Blankenship, James C. ;

Jacobs, Alice K. ;

Morrison, Douglass A. ;

Peterson, Eric D. ;

Whitlow, Patrick L. ;

Williams, David O. ;

Buller, Christopher E. ;

Creager, Mark A. ;

Ettinger, Steven M. ;

Guyton, Robert A. ;

Halperin, Jonathan L. ;

Krumholz, Harlan M. ;

Kushner, Frederick G. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2009, 54 (23) :2205-2241

← 1 2 3 →