Spontaneous intracerebral hemorrhage in CADASIL

被引：23

作者：

Lian, Lifei ^{[1
]}

Li, Dujuan ^{[2
]}

Xue, Zheng ^{[1
]}

Liang, Qiming ^{[1
]}

Xu, Feng ^{[1
]}

Kang, Huicong ^{[1
]}

Liu, Xiaoyan ^{[1
]}

Zhu, Suiqiang ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Neurol, Tongji Med Coll, 1095 Jiefang Ave, Wuhan 430030, Hubei, Peoples R China

[2] Zhengzhou Univ, Peoples Hosp, Henan Prov Peoples Hosp, Dept Pathol, Zhengzhou 450003, Henan, Peoples R China

来源：

JOURNAL OF HEADACHE AND PAIN | 2013年 / 14卷

基金：

中国国家自然科学基金;

关键词：

Migraine; CADASIL; Intracerebral hemorrhage; NOTCH3; Microbleeds; CEREBRAL MICROBLEEDS; ISCHEMIC-STROKE; MUTATION; ASPIRIN;

D O I：

10.1186/1129-2377-14-98

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary small vascular disease and its mainly clinical manifestations are ischemic events. Spontaneous intracerebral hemorrhage (ICH) involvement in patients with CADASIL is extremely uncommon. Case report: A 46-year-old normotensive Chinese man developed a large hematoma in the left basal ganglia after he was diagnosed with CADASIL 2 months ago, the patient did not take any antithrombotics. Susceptibility weighted imaging at pre-ICH showed multiple cerebral microbleeds (CMBs) in the bilateral basal ganglia. He experienced migraine at about 10 months post-ICH. To our knowledge, this is the first report of ICH in CADASIL patients with Arg90Cys mutation in exon 3. Discussion and conclusions: ICH should be considered when evaluating new attacks in CADASIL patients. Thus, MRI screening for CMBs might be helpful in predicting the risk of ICH and guiding antithrombotic therapy. In addition, strict control of hypertension and cautious use of antithrombotics may be important in this context.

引用

页数：6

共 22 条

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