Genetic Control of Gonadal Sex Determination and Development

被引：69

作者：

Stevant, Isabelle ^{[1
,2
,3
]}

Nef, Serge ^{[1
,2
]}

机构：

[1] Univ Geneva, Dept Genet Med & Dev, CH-1211 Geneva, Switzerland

[2] Univ Geneva, iGE3, CH-1211 Geneva, Switzerland

[3] Univ Geneva, SIB, CH-1211 Geneva, Switzerland

来源：

TRENDS IN GENETICS | 2019年 / 35卷 / 05期

基金：

瑞士国家科学基金会;

关键词：

MESONEPHRIC CELL-MIGRATION; CRITICAL TIME WINDOW; SERTOLI-CELLS; GRANULOSA-CELLS; DETERMINATION REVEALS; CANDIDATE GENES; SRY; DIFFERENTIATION; EXPRESSION; FETAL;

D O I：

10.1016/j.tig.2019.02.004

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sex determination is the process by which the bipotential gonads develop as either testes or ovaries. With two distinct potential outcomes, the gonadal primordium offers a unique model for the study of cell fate specification and how distinct cell populations diverge from multipotent progenitors. This review focuses on recent advances in our understanding of the genetic programs and epigenetic mechanisms that regulate gonadal sex determination and the regulation of cell fate commitment in the bipotential gonads. We rely primarily on mouse data to illuminate the complex and dynamic genetic programs controlling cell fate decision and sex-specific cell differentiation during gonadal formation and gonadal sex determination.

引用

页码：346 / 358

页数：13

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