Nonfilamentous C-albicans mutants are avirulent

被引：1508
作者：
Lo, HJ
Kohler, JR
DiDomenico, B
Loebenberg, D
Cacciapuoti, A
Fink, GR
机构：
[1] MIT, WHITEHEAD INST BIOMED RES, CAMBRIDGE, MA 02142 USA
[2] MIT, DEPT BIOL, CAMBRIDGE, MA 02142 USA
[3] CHILDRENS HOSP, DIV INFECT DIS, BOSTON, MA 02115 USA
[4] SCHERING PLOUGH RES INST, KENILWORTH, NJ 07033 USA
来源：
CELL | 1997年 / 90卷 / 05期
关键词：
D O I：
10.1016/S0092-8674(00)80358-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Candida albicans and Saccharomyces cerevisiae switch from a yeast to a filamentous form. In Saccharomyces, this switch is controlled by two regulatory proteins, Ste12p and Phd1p. Single-mutant strains, ste 12/ste12 or phd1/phd1, are partially defective, whereas the sfe12/ste12 phd1/phd1 double mutant is completely defective in filamentous growth and is noninvasive. The equivalent cph1/cph1 efg1/efg1 double mutant in Candida (Cph1p is the Ste12p homolog and Efg1p is the Phd1p homolog) is also defective in filamentous growth, unable to form hyphae or pseudohyphae in response to many stimuli, including serum or macrophages. This Candida cph1/cph1 efg1/efg1 double mutant, locked in the yeast form, is avirulent in a mouse model.
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收藏
页码：939 / 949
页数：11
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