Ribavirin-resistant chronic norovirus infection-associated enteropathy in common variable immunodeficiency. Case report and review of the literature

被引：4
|
作者：
Gonzalez-Morcillo, Gonzalo [1 ]
Calderon-Hernanz, Beatriz [1 ]
Serrano-Lopez Hazas, Joaquin [1 ]
Isabel de Hita-Santabaya, Ana [2 ]
Riera-Oliver, Joan [3 ]
机构：
[1] Son Llatzer Hosp, Serv Farm Hosp, Inst Invest Sanitaria Islas Baleares IdiSba, Dept Pharm, Carretera Manacor Km 4, Palma De Mallorca 07198, Spain
[2] Hosp Univ Son Llatzer, Inst Invest Sanitaria Islas Baleares IdiSba, Dept Pathol, Carretera Manacor Km 4, Palma De Mallorca 07198, Spain
[3] Hosp Univ Son Llatzer, Inst Invest Sanitaria Islas Baleares IdiSba, Gastroenterol Unit, Carretera Manacor Km 4, Palma De Mallorca 07198, Spain
来源：
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2022年 / 46卷 / 08期
关键词：
Norovirus; Common variable immunodeficiency; Intestinal diseases; Ribavirin; Therapeutic drug monitoring;
D O I：
10.1016/j.clinre.2022.101956
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Chronic Norovirus infection is particularly challenging in patients with common variable immunodeficiency (CVID) because of their inability to achieve viral clearance and the risk of developing enteropathy leading to intestinal villous atrophy and malabsorption. To date, therapeutic options to eliminate the virus are limited and only ribavirin has been shown to induce viral clearance in norovirus enteropathy associated with CVID. We report a case of a 48-year-old female patient diagnosed with CVID enteropathy possibly related to norovirus infection who failed a ribavirin-based therapy despite dosage optimization through drug plasma level monitoring.(c) 2022 Elsevier Masson SAS. All rights reserved.
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页数：6
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