Imaging P-Glycoprotein Function at the Blood-Brain Barrier as a Determinant of the Variability in Response to Central Nervous System Drugs

被引：32
作者：
Bauer, Martin [1 ]
Tournier, Nicolas [2 ]
Langer, Oliver [1 ,3 ,4 ]
机构：
[1] Med Univ Vienna, Dept Clin Pharmacol, Vienna, Austria
[2] Univ Paris Saclay, Univ Paris Sud, Serv Hosp Freder Joliot, IMIV,CEA,INSERM,CNRS,UMR 1023, Orsay, France
[3] AIT Austrian Inst Technol GmbH, Preclin Mol Imaging, Seibersdorf, Austria
[4] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Div Nucl Med, Vienna, Austria
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2019年 / 105卷 / 05期
基金：
奥地利科学基金会;
关键词：
EFFLUX;
D O I：
10.1002/cpt.1402
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：1061 / 1064
页数：4
相关论文
共 10 条
[1]   Response to "Impact of Acute Alcohol Exposure on P-Glycoprotein Function at the Blood-Brain Barrier Assessed Using 11C-Metoclopramide PET Imaging" [J].
Hsin, Chih-hsuan ;
Fuhr, Uwe ;
Trueck, Christina .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2019, 105 (04) :814-814
[2]   Why Clinical Modulation of Efflux Transport at the Human Blood-Brain Barrier Is Unlikely: The ITC Evidence-Based Position [J].
Kalvass, J. C. ;
Polli, J. W. ;
Bourdet, D. L. ;
Feng, B. ;
Huang, S-M ;
Liu, X. ;
Smith, Q. R. ;
Zhang, L. K. ;
Zamek-Gliszczynski, M. J. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 94 (01) :80-94
[3]   Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications [J].
Kannan, P. ;
John, C. ;
Zoghbi, S. S. ;
Halldin, C. ;
Gottesman, M. M. ;
Innis, R. B. ;
Hall, M. D. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 86 (04) :368-377
[4]   Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using 11C-Verapamil in the Brain: Studies of Healthy Humans [J].
Muzi, Mark ;
Mankoff, David A. ;
Link, Jeanne M. ;
Shoner, Steve ;
Collier, Ann C. ;
Sasongko, Lucy ;
Unadkat, Jashvant D. .
JOURNAL OF NUCLEAR MEDICINE, 2009, 50 (08) :1267-1275
[5]   Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide [J].
Pottier, Geraldine ;
Marie, Solene ;
Goutal, Sebastien ;
Auvity, Sylvain ;
Peyronneau, Marie-Anne ;
Stute, Simon ;
Boisgard, Raphael ;
Dolle, Frederic ;
Buvat, Irene ;
Caille, Fabien ;
Tournier, Nicolas .
JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (02) :309-314
[6]   DISRUPTION OF THE MOUSE MDR1A P-GLYCOPROTEIN GENE LEADS TO A DEFICIENCY IN THE BLOOD-BRAIN-BARRIER AND TO INCREASED SENSITIVITY TO DRUGS [J].
SCHINKEL, AH ;
SMIT, JJM ;
VANTELLINGEN, O ;
BEIJNEN, JH ;
WAGENAAR, E ;
VANDEEMTER, L ;
MOL, CAAM ;
VANDERVALK, MA ;
ROBANUSMAANDAG, EC ;
TERIELE, HPJ ;
BERNS, AJM ;
BORST, P .
CELL, 1994, 77 (04) :491-502
[7]   Pharmacokinetic consequences of active drug efflux at the blood-brain barrier [J].
Syvänen, S ;
Xie, RJ ;
Sahin, S ;
Hammarlund-Udenaes, M .
PHARMACEUTICAL RESEARCH, 2006, 23 (04) :705-717
[8]   Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans [J].
Tournier, Nicolas ;
Bauer, Martin ;
Pichler, Verena ;
Nics, Lukas ;
Klebermass, Eva-Maria ;
Bamminger, Karsten ;
Matzneller, Peter ;
Weber, Maria ;
Karch, Rudolf ;
Caille, Fabien ;
Auvity, Sylvain ;
Marie, Solene ;
Jaeger, Walter ;
Wadsak, Wolfgang ;
Hacker, Marcus ;
Zeitlinger, Markus ;
Langer, Oliver .
JOURNAL OF NUCLEAR MEDICINE, 2019, 60 (07) :985-991
[9]   Imaging techniques to study drug transporter function in vivo [J].
Tournier, Nicolas ;
Stieger, Bruno ;
Langer, Oliver .
PHARMACOLOGY & THERAPEUTICS, 2018, 189 :104-122
[10]   Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography [J].
Wanek, Thomas ;
Roemermann, Kerstin ;
Mairinger, Severin ;
Stanek, Johann ;
Sauberer, Michael ;
Filip, Thomas ;
Traxl, Alexander ;
Kuntner, Claudia ;
Pahnke, Jens ;
Bauer, Florian ;
Erker, Thomas ;
Loescher, Wolfgang ;
Mueller, Markus ;
Langer, Oliver .
MOLECULAR PHARMACEUTICS, 2015, 12 (09) :3214-3225
1