Imaging P-Glycoprotein Function at the Blood-Brain Barrier as a Determinant of the Variability in Response to Central Nervous System Drugs

被引:30
作者
Bauer, Martin [1 ]
Tournier, Nicolas [2 ]
Langer, Oliver [1 ,3 ,4 ]
机构
[1] Med Univ Vienna, Dept Clin Pharmacol, Vienna, Austria
[2] Univ Paris Saclay, Univ Paris Sud, Serv Hosp Freder Joliot, IMIV,CEA,INSERM,CNRS,UMR 1023, Orsay, France
[3] AIT Austrian Inst Technol GmbH, Preclin Mol Imaging, Seibersdorf, Austria
[4] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Div Nucl Med, Vienna, Austria
基金
奥地利科学基金会;
关键词
EFFLUX;
D O I
10.1002/cpt.1402
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:1061 / 1064
页数:4
相关论文
共 10 条
  • [1] Response to "Impact of Acute Alcohol Exposure on P-Glycoprotein Function at the Blood-Brain Barrier Assessed Using 11C-Metoclopramide PET Imaging"
    Hsin, Chih-hsuan
    Fuhr, Uwe
    Trueck, Christina
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2019, 105 (04) : 814 - 814
  • [2] Why Clinical Modulation of Efflux Transport at the Human Blood-Brain Barrier Is Unlikely: The ITC Evidence-Based Position
    Kalvass, J. C.
    Polli, J. W.
    Bourdet, D. L.
    Feng, B.
    Huang, S-M
    Liu, X.
    Smith, Q. R.
    Zhang, L. K.
    Zamek-Gliszczynski, M. J.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2013, 94 (01) : 80 - 94
  • [3] Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications
    Kannan, P.
    John, C.
    Zoghbi, S. S.
    Halldin, C.
    Gottesman, M. M.
    Innis, R. B.
    Hall, M. D.
    [J]. CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 86 (04) : 368 - 377
  • [4] Imaging of Cyclosporine Inhibition of P-Glycoprotein Activity Using 11C-Verapamil in the Brain: Studies of Healthy Humans
    Muzi, Mark
    Mankoff, David A.
    Link, Jeanne M.
    Shoner, Steve
    Collier, Ann C.
    Sasongko, Lucy
    Unadkat, Jashvant D.
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2009, 50 (08) : 1267 - 1275
  • [5] Imaging the Impact of the P-Glycoprotein (ABCB1) Function on the Brain Kinetics of Metoclopramide
    Pottier, Geraldine
    Marie, Solene
    Goutal, Sebastien
    Auvity, Sylvain
    Peyronneau, Marie-Anne
    Stute, Simon
    Boisgard, Raphael
    Dolle, Frederic
    Buvat, Irene
    Caille, Fabien
    Tournier, Nicolas
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (02) : 309 - 314
  • [6] DISRUPTION OF THE MOUSE MDR1A P-GLYCOPROTEIN GENE LEADS TO A DEFICIENCY IN THE BLOOD-BRAIN-BARRIER AND TO INCREASED SENSITIVITY TO DRUGS
    SCHINKEL, AH
    SMIT, JJM
    VANTELLINGEN, O
    BEIJNEN, JH
    WAGENAAR, E
    VANDEEMTER, L
    MOL, CAAM
    VANDERVALK, MA
    ROBANUSMAANDAG, EC
    TERIELE, HPJ
    BERNS, AJM
    BORST, P
    [J]. CELL, 1994, 77 (04) : 491 - 502
  • [7] Pharmacokinetic consequences of active drug efflux at the blood-brain barrier
    Syvänen, S
    Xie, RJ
    Sahin, S
    Hammarlund-Udenaes, M
    [J]. PHARMACEUTICAL RESEARCH, 2006, 23 (04) : 705 - 717
  • [8] Impact of P-Glycoprotein Function on the Brain Kinetics of the Weak Substrate 11C-Metoclopramide Assessed with PET Imaging in Humans
    Tournier, Nicolas
    Bauer, Martin
    Pichler, Verena
    Nics, Lukas
    Klebermass, Eva-Maria
    Bamminger, Karsten
    Matzneller, Peter
    Weber, Maria
    Karch, Rudolf
    Caille, Fabien
    Auvity, Sylvain
    Marie, Solene
    Jaeger, Walter
    Wadsak, Wolfgang
    Hacker, Marcus
    Zeitlinger, Markus
    Langer, Oliver
    [J]. JOURNAL OF NUCLEAR MEDICINE, 2019, 60 (07) : 985 - 991
  • [9] Imaging techniques to study drug transporter function in vivo
    Tournier, Nicolas
    Stieger, Bruno
    Langer, Oliver
    [J]. PHARMACOLOGY & THERAPEUTICS, 2018, 189 : 104 - 122
  • [10] Factors Governing P-Glycoprotein-Mediated Drug-Drug Interactions at the Blood-Brain Barrier Measured with Positron Emission Tomography
    Wanek, Thomas
    Roemermann, Kerstin
    Mairinger, Severin
    Stanek, Johann
    Sauberer, Michael
    Filip, Thomas
    Traxl, Alexander
    Kuntner, Claudia
    Pahnke, Jens
    Bauer, Florian
    Erker, Thomas
    Loescher, Wolfgang
    Mueller, Markus
    Langer, Oliver
    [J]. MOLECULAR PHARMACEUTICS, 2015, 12 (09) : 3214 - 3225