Fabrication, properties and bioapplications of cellulose/collagen hydrolysate composite films

被引：67
作者：
Pei, Ying [1 ]
Yang, Juan [1 ]
Liu, Pan [1 ]
Xu, Min [2 ]
Zhang, Xianzheng [1 ]
Zhang, Lina [1 ]
机构：
[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China
[2] E China Normal Univ, Dept Phys, Shanghai 20041, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2013年 / 92卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Cellulose; Collagen hydrolysate; Composite film; Non-covalent bond; Biocompatibility; BIODEGRADABLE PACKING MATERIALS; SODIUM CARBOXYMETHYL CELLULOSE; MECHANICAL-PROPERTIES; SOLID-STATE; THERMOPLASTIC BLENDS; COLLAGEN HYDROLYSATE; BACTERIAL CELLULOSE; CROSS-LINKING; GENE VECTOR; GELATIN;
D O I：
10.1016/j.carbpol.2012.11.029
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
In this work, a series of cellulose/collagen hydrolysate (RC/CH) films were prepared in NaOH/urea aqueous solution via a simple, low-cost and green pathway. To overcome the disadvantages (brittleness, poor water resistance) of CH as biomaterials, CH was combined with regenerated cellulose (RC) film to construct RC/CH composite materials, leading to vast improvement of the water resistance of CH. Crosslinking with genipin further improved the mechanical properties of the RC/CH films in the wet state. Their structure and properties were characterized by elemental analysis, Fourier transform infra-red (FT-IR) spectra, ultraviolet-visible (UV-vis), scanning electron microscopy (SEM), amino acid analysis, tensile testing, cell adhesion and toxicity tests. The mechanical properties and water resistance of the crosslinked RC/CH films were significantly improved, which made collagen hydrolysate as biomaterial could be used at wet state. Moreover, the RC/CH films exhibited good biocompatibility by proliferation of COS7 cells on the surface, supporting cell adhesion and growth. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1752 / 1760
页数：9
相关论文
共 61 条
[1]   Poly(vinyl alcohol)-collagen hydrolysate thermoplastic blends:: II.: Water penetration and biodegradability of melt extruded films [J].
Alexy, P ;
Bakos, D ;
Crkonová, G ;
Kramárová, Z ;
Hoffmann, J ;
Julinová, M ;
Chiellini, E ;
Cinelli, P .
POLYMER TESTING, 2003, 22 (07) :811-818
[2]   Poly(vinyl alcohol)-collagen hydrolysate thermoplastic blends:: I.: Experimental design optimisation and biodegradation behaviour [J].
Alexy, P ;
Bakos, D ;
Hanzelová, S ;
Kukolíková, L ;
Kupec, J ;
Charvátová, K ;
Chiellini, E ;
Cinelli, P .
POLYMER TESTING, 2003, 22 (07) :801-809
[3]   Stabilization of gelatin films by crosslinking with genipin [J].
Bigi, A ;
Cojazzi, G ;
Panzavolta, S ;
Roveri, N ;
Rubini, K .
BIOMATERIALS, 2002, 23 (24) :4827-4832
[4]   Bacterial cellulose as a potential meniscus implant [J].
Bodin, Aase ;
Concaro, Sebastian ;
Brittberg, Mats ;
Gatenholm, Paul .
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2007, 1 (05) :406-408
[5]   Rapid dissolution of cellulose in LiOH/Urea and NaOH/Urea aqueous solutions [J].
Cai, J ;
Zhang, L .
MACROMOLECULAR BIOSCIENCE, 2005, 5 (06) :539-548
[6]   Multifilament fibers based on dissolution of cellulose in NaOH/urea aqueous solution: Structure and properties [J].
Cai, Jie ;
Zhang, Lina ;
Zhou, Jinping ;
Qi, Haisong ;
Chen, Hui ;
Kondo, Tetsuo ;
Chen, Xuming ;
Chu, Benjamin .
ADVANCED MATERIALS, 2007, 19 (06) :821-+
[7]   Dilute solution properties of cellulose in LiOH/urea aqueous system [J].
Cai, Jie ;
Liu, Yating ;
Zhang, Lina .
JOURNAL OF POLYMER SCIENCE PART B-POLYMER PHYSICS, 2006, 44 (21) :3093-3101
[8]  
Cai Z., 2010, J NANOTECHNOLOGY ENG, V1
[9]   Collagen tissue engineering: Development of novel biomaterials and applications [J].
Cen, Lian ;
Liu, Wei ;
Cui, Lei ;
Zhang, Wenjie ;
Cao, Yilin .
PEDIATRIC RESEARCH, 2008, 63 (05) :492-496
[10]   Structure and properties of hydrogels prepared from cellulose in NaOH/urea aqueous solutions [J].
Chang, Chunyu ;
Zhang, Lingzhi ;
Zhou, Jinping ;
Zhang, Lina ;
Kennedy, John F. .
CARBOHYDRATE POLYMERS, 2010, 82 (01) :122-127
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