Lewis acid-promoted coupling reactions of acid chlorides with organoaluminum and organozinc reagents

被引：39

作者：

Arisawa, M ^{[1
]}

Torisawa, Y ^{[1
]}

Kawahara, M ^{[1
]}

Yamanaka, M ^{[1
]}

Nishida, A ^{[1
]}

Nakagawa, M ^{[1
]}

机构：

[1] CHIBA UNIV,FAC PHARMACEUT SCI,INAGE KU,CHIBA 263,JAPAN

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 13期

关键词：

D O I：

10.1021/jo970244a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of alpha,beta-unsaturated ketones by the reaction of acid chlorides with trialkylaluminum (1/3 mole equiv) in the presence of AlCl3 (1 mol equiv) is described. Dialkylzincs were also useful and are easier to prepare than trialkylaluminum. Reaction of RCOCl with R'AlCl2 or R-2'AlCl gave R'COR, without AlCl3, in high yield.

引用

页码：4327 / 4329

页数：3

共 23 条

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