Goal-directed actions transiently depend on dorsal hippocampus

被引：28
作者：
Bradfield, Laura A. [1 ,2 ]
Leung, Beatrice K. [3 ]
Boldt, Susan [4 ]
Liang, Sophia [3 ]
Balleine, Bernard W. [3 ]
机构：
[1] Univ Technol Sydney, Ctr Neurosci & Regenerat Med, Sydney, NSW, Australia
[2] St Vincents Hlth Network, St Vincents Ctr Appl Med Res, Sydney, NSW, Australia
[3] Univ New South Wales, Sch Psychol, Decis Neurosci Lab, Sydney, NSW, Australia
[4] Univ Sydney, Sch Psychol, Sydney, NSW, Australia
来源：
NATURE NEUROSCIENCE | 2020年 / 23卷 / 10期
基金：
英国医学研究理事会;
关键词：
MEMORY; CONTINGENCY; CORTEX;
D O I：
10.1038/s41593-020-0693-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study shows that the dorsal hippocampus is necessary for goal-directed action, but only transiently, during initial learning. Convergently, goal-directed actions also depend transiently on the physical context. The role of the hippocampus in goal-directed action is currently unclear; studies investigating this issue have produced contradictory results. Here we reconcile these contradictions by demonstrating that, in rats, goal-directed action relies on the dorsal hippocampus, but only transiently, immediately after initial acquisition. Furthermore, we found that goal-directed action also depends transiently on physical context, suggesting a psychological basis for the hippocampal regulation of goal-directed action control.
引用
收藏
页码：1194 / +
页数：17
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