Retinal pigment epithelium, age-related macular degeneration and neurotrophic keratouveitis

被引：35

作者：

Bianchi, Enrica ^{[1
]}

Scarinci, Fabio ^{[2
]}

Ripandelli, Guido ^{[2
]}

Feher, Janos ^{[1
]}

Pacella, Elena ^{[1
]}

Magliulo, Giuseppe ^{[1
]}

Gabrieli, Corrado Balacco ^{[1
]}

Plateroti, Rocco ^{[1
]}

Plateroti, Pasquale ^{[1
]}

Mignini, Fiorenzo ^{[3
]}

Artico, Marco ^{[1
]}

机构：

[1] Univ Roma La Sapienza, Dept Sensory Organs, I-00161 Rome, Italy

[2] Bietti Eye Fdn IRCCS, Rome, Italy

[3] Univ Camerino, Sch Drug & Hlth Prod Sci, I-62032 Camerino, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | 2013年 / 31卷 / 01期

关键词：

retinal pigment epithelium; mitochondria; lipofuscin; peroxisomes; age-related macular degeneration; pigment epithelium-derived factor; light microscopy; electron microscopy; morphometry; ENDOTHELIAL GROWTH-FACTOR; ACTIVATED RECEPTORS ALPHA; FATTY-ACIDS; MITOCHONDRIAL DYSFUNCTION; PERMEABILITY TRANSITION; SUBSTANCE-P; NEUROGENIC INFLAMMATION; NEURONAL DEGENERATION; GENE-EXPRESSION; CELL-FUNCTION;

D O I：

10.3892/ijmm.2012.1164

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Age-related macular degeneration (AMD) is the leading cause of impaired vision and blindness in the aging population. The aims of our studies were to identify qualitative and quantitative alterations in mitochondria in human retinal pigment epithelium (RPE) from AMD patients and controls and to test the protective effects of pigment epithelium-derived factor (PEDF), a known neurotrophic and antiangiogenic substance, against neurotrophic keratouveitis. Histopathological alterations were studied by means of morphometry, light and electron microscopy. Unexpectedly, morphometric data showed that the RPE alterations noted in A MD may also develop in normal aging, 10-15 years later than appearing in AMD patients. Reduced tear secretion, corneal ulceration and leukocytic infiltration were found in capsaicin (CAP)-treated rats, but this effect was significantly attenuated by PEDF. These findings suggest that PEDF accelerated the recovery of tear secretion and also prevented neurotrophic keratouveitis and vitreoretinal inflammation. PEDF may have a clinical application in inflammatory and neovascular diseases of the eye.

引用

页码：232 / 242

页数：11

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