Adipose Tissue Regeneration: A State of the Art

被引：51

作者：

Casadei, Alessandro ^{[2
]}

Epis, Roberta ^{[3
]}

Ferroni, Letizia ^{[1
]}

Tocco, Ilaria ^{[4
]}

Gardin, Chiara ^{[1
]}

Bressan, Eriberto ^{[4
,5
,6
]}

Sivolella, Stefano ^{[4
,5
,6
]}

Vindigni, Vincenzo ^{[4
]}

Pinton, Paolo ^{[5
,6
]}

Mucci, Giuseppe ^{[3
]}

Zavan, Barbara ^{[1
]}

机构：

[1] Univ Padua, Dept Biomed Sci, I-35100 Padua, Italy

[2] Casadei Clin, I-30174 Venice, Italy

[3] Biosci Inst, I-47891 Falciano, San Marino, Italy

[4] Univ Padua, Dept Neurosci, I-35100 Padua, Italy

[5] Univ Ferrara, LTTA Ctr, I-44121 Ferrara, Italy

[6] Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, ICSI, I-44121 Ferrara, Italy

来源：

JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY | 2012年

关键词：

MESENCHYMAL STEM-CELLS; HUMAN BONE-MARROW; FIBROBLAST-GROWTH-FACTOR; LONG-TERM SURVIVAL; IN-VITRO; STROMAL CELLS; GELATIN MICROSPHERES; HUMAN PREADIPOCYTES; BASEMENT-MEMBRANE; DIFFERENTIATION;

D O I：

10.1155/2012/462543

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Adipose tissue pathologies and defects have always represented a reconstructive challenge for plastic surgeons. In more recent years, several allogenic and alloplastic materials have been developed and used as fillers for soft tissue defects. However, their clinical use has been limited by further documented complications, such as foreign-body reactions potentially affecting function, degradation over time, and the risk for immunogenicity. Tissue-engineering strategies are thus being investigated to develop methods for generating adipose tissue. This paper will discuss the current state of the art in adipose tissue engineering techniques, exploring the biomaterials used, stem cells application, culture strategies, and current regulatory framework that are in use are here described and discussed.

引用

页数：12

共 118 条

[1] Myogel, a novel, basement membrane-rich, extracellular matrix derived from skeletal muscle, is highly adipogenic in vivo and in vitro [J].