Neuroprotective effects of extracellular DJ-1 on reperfusion injury in SH-SY5Y cells

被引：6

作者：

Han, Jay ^{[1
]}

Luk, Beryl ^{[1
]}

Lee, Frank J. S. ^{[1
]}

机构：

[1] Simon Fraser Univ, Fac Hlth Sci, Burnaby, BC V5A 1S6, Canada

来源：

SYNAPSE | 2017年 / 71卷 / 05期

基金：

加拿大自然科学与工程研究理事会;

关键词：

OGD; hypoxia; cell death; PARK7; IN-VITRO MODEL; PARKINSONS-DISEASE; OXIDATIVE STRESS; ISCHEMIA; STROKE; DJ-1/PARK7; MUTATIONS; REGULATOR; PROTECTS; PATHWAY;

D O I：

10.1002/syn.21963

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using an in vitro model of ischemic stroke we treated differentiated SH-SY5Y cells to oxygenglucose deprivation (OGD) followed by a reperfusion period where normal growth conditions were restored. Cells undergoing OGD exhibited significant cell death as measure by propidium iodide staining. However, cells treated with exogenous extracellular DJ-1 during reperfusion exhibited significant rescue from OGD-induced cell death.

引用

页数：5