The rapid divergence of the ecdysone receptor is a synapomorphy for Mecopterida that clarifies the Strepsiptera problem

被引：34

作者：

Bonneton, F.

Brunet, F. G.

Kathirithamby, J.

Laudet, V.

机构：

[1] Ecole Normale Super Lyon, CNRS, INRA, Lab Biol Mol Cellule,UMR 5161,LA 1237,IFR BioSci, F-69364 Lyon 07, France

[2] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

INSECT MOLECULAR BIOLOGY | 2006年 / 15卷 / 03期

关键词：

ecdysone receptor; USP/RXR; ECR; Mecopterida; Strepsiptera;

D O I：

10.1111/j.1365-2583.2006.00654.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In arthropods, the regulation by ecdysteroids is mediated by the heterodimer between the ecdysone receptor (ECR; NR1H1) and ultraspiracle (USP/RXR; NR2B4) nuclear receptors. Both ECR and USP/RXR ligand-binding domains experienced a strong acceleration of evolutionary rate in Diptera and Lepidoptera, which belong to the superorder Mecopterida. We performed a phylogenetic analysis of 28 ECR and 30 USP/RXR protein sequences from 36 arthropod species, including representatives from Trichoptera, Mecoptera and Siphonaptera. Our data show that the acceleration of ECR and USP/RXR was a unique event in the ancestor of Mecopterida. Our analysis shows further that Strepsiptera ECR and USP/RXR sequences are unambiguously placed outside of the Mecopterida clade. Protein alignments reveal that eight of 11 synapomorphies support an affinity between Strepsiptera and Coleoptera sequences. The affiliation of Strepsiptera to Diptera should therefore be rejected.

引用

页码：351 / 362

页数：12

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