BDNF val66met polymorphism is associated with modified experience-dependent plasticity in human motor cortex

被引：405

作者：

Kleim, Jeffrey A.

Chan, Sheila

Pringle, Erin

Schallert, Kellan

Procaccio, Vincent

Jimenez, Richard

Cramer, Steven C.

机构：

[1] Malcorn Randall VA Hosp, Brain Res Rehabil Ctr, Gainesville, FL 32608 USA

[2] Univ Florida, Dept Neurosci, Mcknight Brain Inst, Gainesville, FL 32610 USA

[3] Univ Calif Irvine, Ctr Med, Dept Neurol, Orange, CA 92868 USA

[4] Univ Calif Irvine, Ctr Med, Dept Anat & Neurobiol, Orange, CA 92868 USA

[5] Univ Calif Irvine, Dept Pediat, Irvine, CA 92697 USA

[6] Univ Calif Irvine, Ctr Mol & Mitochondrial Med & Genet, Irvine, CA 92697 USA

来源：

NATURE NEUROSCIENCE | 2006年 / 9卷 / 06期

关键词：

D O I：

10.1038/nn1699

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Motor training can induce profound physiological plasticity within primary motor cortex, including changes in corticospinal output and motor map topography. Using transcranial magnetic stimulation, we show that training-dependent increases in the amplitude of motor-evoked potentials and motor map reorganization are reduced in healthy subjects with a val66met polymorphism in the brain-derived neurotrophic factor gene ( BDNF), as compared to subjects without the polymorphism. The results suggest that BDNF is involved in mediating experience-dependent plasticity of human motor cortex.

引用

收藏

页码：735 / 737

页数：3

相关论文

共 14 条

[1] Rapid plasticity of human cortical movement representation induced by practice [J].

Classen, J ;

Liepert, J ;

Wise, SP ;

Hallett, M ;

Cohen, LG .

JOURNAL OF NEUROPHYSIOLOGY, 1998, 79 (02) :1117-1123

[2] Association between BDNF Val66Met genotype and episodic memory [J].

Dempster, E ;

Toulopoulou, T ;

McDonald, C ;

Bramon, E ;

Walshe, M ;

Filbey, F ;

Wickham, H ;

Sham, PC ;

Murray, RM ;

Collier, DA .

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2005, 134B (01) :73-75

[3] The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function [J].

Egan, MF ;

Kojima, M ;

Callicott, JH ;

Goldberg, TE ;

Kolachana, BS ;

Bertolino, A ;

Zaitsev, E ;

Gold, B ;

Goldman, D ;

Dean, M ;

Lu, B ;

Weinberger, DR .

CELL, 2003, 112 (02) :257-269

[4] Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance [J].

Hariri, AR ;

Goldberg, TE ;

Mattay, VS ;

Kolachana, BS ;

Callicott, JH ;

Egan, MF ;

Weinberger, DR .

JOURNAL OF NEUROSCIENCE, 2003, 23 (17) :6690-6694

[5] Motor enrichment and the induction of plasticity before or after brain injury [J].

Kleim, JA ;

Jones, TA ;

Schallert, T .

NEUROCHEMICAL RESEARCH, 2003, 28 (11) :1757-1769

[6] Altered expression of BDNF and its high-affinity receptor TrkB in response to complex motor learning and moderate exercise [J].

Klintsova, AY ;

Dickson, E ;

Yoshida, R ;

Greenough, WT .

BRAIN RESEARCH, 2004, 1028 (01) :92-104

[7] BDNF and activity-dependent synaptic modulation [J].

Lu, B .

LEARNING & MEMORY, 2003, 10 (02) :86-98

[8] In search of the motor engram: Motor map plasticity as a mechanism for encoding motor experience [J].

Monfils, MH ;

Plautz, EJ ;

Kleim, JA .

NEUROSCIENTIST, 2005, 11 (05) :471-483

[9]

Oefner P. J., 1998, CURRENT PROTOCOLS HU

[10] MODULATION OF MUSCLE RESPONSES EVOKED BY TRANSCRANIAL MAGNETIC STIMULATION DURING THE ACQUISITION OF NEW FINE MOTOR-SKILLS [J].

PASCUALLEONE, A ;

DANG, N ;

COHEN, LG ;

BRASILNETO, JP ;

CAMMAROTA, A ;

HALLETT, M .

JOURNAL OF NEUROPHYSIOLOGY, 1995, 74 (03) :1037-1045