Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor

被引：9
|
作者：
Ghanemi, Abdelaziz [1 ,2 ]
Yoshioka, Mayumi [2 ]
St-Amand, Jonny [1 ,2 ]
机构：
[1] Laval Univ, Fac Med, Dept Mol Med, Quebec City, PQ G1V 0A6, Canada
[2] Univ Laval, Funct Genom Lab, CHU Quebec, Res Ctr,Endocrinol & Nephrol Axis, Quebec City, PQ G1V 4G2, Canada
来源：
ANIMALS | 2020年 / 10卷 / 09期
关键词：
trefoil factor family member 2 (TFF2); inflammation; tissue repair; SPASMOLYTIC POLYPEPTIDE; ACID-SECRETION; GASTRIC-MUCOSA; CELL LINEAGE; MICE LACKING; EXPRESSION; RECEPTOR; PEPTIDE; ALPHA; ACTIVATION;
D O I：
10.3390/ani10091646
中图分类号：
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号：
0905 ;
摘要：
Trefoil factor family member 2 (TFF2) is known for its involvement in mucosal repair. Whereas it is overexpressed during inflammatory processes, adding TFF2 leads to an anti-inflammatory effect that would contribute to create the microenvironment required for tissue repair. These properties present TFF2 with a homeostatic pattern during inflammatory processes as illustrated by selected examples.
引用
收藏
页数：6
相关论文
共 50 条
  • [1] Trefoil Factor Family Member 2 (Tff2) KO Mice Are protected from High-Fat Diet-Induced Obesity
    De Giorgio, Maria Rita
    Yoshioka, Mayumi
    Riedl, Isabelle
    Moreault, Olivier
    Cherizol, Rose-Guerline
    Shah, Aftab Ali
    Blin, Nikolaus
    Richard, Denis
    St-Amand, Jonny
    OBESITY, 2013, 21 (07) : 1389 - 1395
  • [2] Trefoil Factor 2 (TFF2) Induces Proliferation of Pancreatic β Cells
    Orime, Kazuki
    DIABETES, 2011, 60 : A531 - A531
  • [3] In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase
    Xue, Lin
    Aihara, Eitaro
    Podolsky, Daniel K.
    Wang, Timothy C.
    Montrose, Marshall H.
    GUT, 2010, 59 (09) : 1184 - 1191
  • [4] Trefoil factor 2 (TFF2) is induced by allergen and IL-13 in lung goblet cells and modulates airway inflammatory cell number
    Nikolaidis, NM
    Fulkerson, PC
    Wang, TC
    Rothenberg, ME
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2006, 117 (02) : S142 - S142
  • [5] Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine
    Margarita Rinnert
    Margitta Hinz
    Peter Buhtz
    Frank Reiher
    Wolfgang Lessel
    Werner Hoffmann
    Cell and Tissue Research, 2010, 339 : 639 - 647
  • [6] Synthesis and localization of trefoil factor family (TFF) peptides in the human urinary tract and TFF2 excretion into the urine
    Rinnert, Margarita
    Hinz, Margitta
    Buhtz, Peter
    Reiher, Frank
    Lessel, Wolfgang
    Hoffmann, Werner
    CELL AND TISSUE RESEARCH, 2010, 339 (03) : 639 - 647
  • [7] High-Fat Diet-Induced Trefoil Factor Family Member 2 (TFF2) to Counteract the Immune-Mediated Damage in Mice
    Ghanemi, Abdelaziz
    Yoshioka, Mayumi
    St-Amand, Jonny
    ANIMALS, 2021, 11 (02): : 1 - 5
  • [8] Trefoil family factor 2 (TFF2) results in disruption of intercellular junctions facilitating cell migration and restitution
    Moncur, PH
    Askham, J
    Markham, AF
    Morrison, EE
    GUT, 2000, 46 : A57 - A57
  • [9] TFF2 (trefoil family factor2) inhibits apoptosis in breast and colorectal cancer cell lines
    Siu, LS
    Romanska, H
    Abel, PD
    Baus-Loncar, M
    Kayademir, T
    Stamp, GWH
    Lalani, EN
    PEPTIDES, 2004, 25 (05) : 855 - 863
  • [10] Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat
    Poulsen, SS
    Thulesen, J
    Christensen, L
    Nexo, E
    Thim, L
    GUT, 1999, 45 (04) : 516 - 522
12345