Aplyronine A, a potent antitumour macrolide of marine origin, and the congeners aplyronines B-H: chemistry and biology

被引：57

作者：

Yamada, Kiyoyuki ^{[1
]}

Ojika, Makoto ^{[2
]}

Kigoshi, Hideo ^{[3
]}

Suenaga, Kiyotake ^{[4
]}

机构：

[1] Nagoya Univ, Grad Sch Sci, Chikusa Ku, Nagoya, Aichi 4648602, Japan

[2] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[3] Univ Tsukuba, Grad Sch Pure & Appl Sci, Tsukuba, Ibaraki 3058571, Japan

[4] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

NATURAL PRODUCT REPORTS | 2009年 / 26卷 / 01期

关键词：

ACTIN-DEPOLYMERIZING ACTIVITY; HARE APLYSIA-KURODAI; PI-FACE SELECTIVITY; STEREOCONTROLLED SYNTHESIS; ABSOLUTE STEREOCHEMISTRY; ASYMMETRIC-SYNTHESIS; ALDOL REACTIONS; POLYPROPIONATE SYNTHESIS; MYCALOLIDE ANALOGS; ARTIFICIAL ANALOGS;

D O I：

10.1039/b800263k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aplyronines A-H are cytotoxic macrolides isolated from the sea hare Aplysia kurodai. Aplyronine A is the major constituent among the aplyronines, and this review concentrates on the results of chemical and biological research into this natural product. The isolation, determination of stereostructure and enantioselective total synthesis of the aplyronines are covered, together with discussion of their antitumour activity and structure-activity relationships, and the three-dimensional X-ray structure of the actin-aplyronine A complex.

引用

页码：27 / 43

页数：17

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