A critical analysis of the role of gut Oxalobacter formigenes in oxalate stone disease

被引:51
作者
Siva, Siddharth [1 ]
Barrack, Evelyn R. [1 ]
Reddy, G. Prem Veer [1 ]
Thamilselvan, Vijayalakshmi [1 ]
Thamilselvan, Sivagnanam [1 ]
Menon, Mani [1 ]
Bhandari, Mahendra [1 ]
机构
[1] Henry Ford Hosp, Vattikuti Urol Inst, Detroit, MI 48202 USA
关键词
Oxalobacter formigenes; oxalate; transporters; hyperoxaluria; kidney stones; colonization; URINARY OXALATE; LACTOBACILLUS-ACIDOPHILUS; COA DECARBOXYLASE; ANION-EXCHANGER; EXCRETION; SLC26A6; COLONIZATION; UROLITHIASIS; RISK; NEPHROLITHIASIS;
D O I
10.1111/j.1464-410X.2008.08122.x
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Hyperoxaluria is a major risk factor for the formation of calcium oxalate stones, but dietary restriction of oxalate intake might not be a reliable approach to prevent recurrence of stones. Hence, other approaches to reduce urinary oxalate to manage stone disease have been explored. The gut-dwelling obligate anaerobe Oxalobacter formigenes (OF) has attracted attention for its oxalate-degrading property. In this review we critically evaluate published studies and identify major gaps in knowledge. Recurrent stone-formers are significantly less likely to be colonized with OF than controls, but this appears to be due to antibiotic use. Studies in animals and human subjects show that colonization of the gut with OF can decrease urinary oxalate levels. However, it remains to be determined whether colonization with OF can affect stone disease. Reliable methods are needed to detect and quantify colonization status and to achieve durable colonization. New information about oxalate transport mechanisms raises hope for pharmacological manipulation to decrease urinary oxalate levels. In addition, probiotic use of lactic acid bacteria that metabolize oxalate might provide a valid alternative to OF.
引用
收藏
页码:18 / 21
页数:4
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