Intramolecular Diels-Alder reaction for the synthesis of tetracyclic carbazoles and isocanthines

被引：20
|
作者：
Naik, Prajakta N. [1 ]
Khan, Ayesha [1 ]
Kusurkar, Radhika S. [1 ]
机构：
[1] Univ Pune, Dept Chem, Pune 411007, Maharashtra, India
来源：
TETRAHEDRON | 2013年 / 69卷 / 50期
关键词：
Intramolecular Diels-Alder reaction; Isocanthine; Tetracyclic carbazole; alpha; beta-Unsaturated hydrazone; CANTHINE ANALOGS; ARYLATION; ROUTE;
D O I：
10.1016/j.tet.2013.10.054
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One pot intramolecular Diels-Alder reaction has been efficiently used as a new route for the synthesis of four tetracyclic carbazoles and four isocanthine analogues where a dialdehyde is utilised as a common intermediate for both the scaffolds. Biological activity was evaluated for some molecules, which demonstrated moderate activity against HeLa cervical cancer cell lines (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：10733 / 10738
页数：6
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