Intramolecular Diels-Alder reaction for the synthesis of tetracyclic carbazoles and isocanthines

被引：20
|
作者：
Naik, Prajakta N. [1 ]
Khan, Ayesha [1 ]
Kusurkar, Radhika S. [1 ]
机构：
[1] Univ Pune, Dept Chem, Pune 411007, Maharashtra, India
来源：
TETRAHEDRON | 2013年 / 69卷 / 50期
关键词：
Intramolecular Diels-Alder reaction; Isocanthine; Tetracyclic carbazole; alpha; beta-Unsaturated hydrazone; CANTHINE ANALOGS; ARYLATION; ROUTE;
D O I：
10.1016/j.tet.2013.10.054
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
One pot intramolecular Diels-Alder reaction has been efficiently used as a new route for the synthesis of four tetracyclic carbazoles and four isocanthine analogues where a dialdehyde is utilised as a common intermediate for both the scaffolds. Biological activity was evaluated for some molecules, which demonstrated moderate activity against HeLa cervical cancer cell lines (C) 2013 Elsevier Ltd. All rights reserved.
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收藏
页码：10733 / 10738
页数：6
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