Steroid Receptor Ligands for Breast Cancer Targeting: An Insight into Their Potential Role As Pet Imaging Agents

被引：14

作者：

Oliveira, M. C. ^{[1
]}

Neto, C. ^{[1
]}

Ribeiro Morais, G. ^{[1
]}

Thiemann, T. ^{[2
]}

机构：

[1] Univ Tecn Lisboa, Inst Super Tecn, IST ITN, Unidade Ciencias Quim & Radiofarmaceut, P-2686953 Sacavem, Portugal

[2] United Arab Emirates Univ, Fac Sci, Al Ain, U Arab Emirates

来源：

CURRENT MEDICINAL CHEMISTRY | 2013年 / 20卷 / 02期

关键词：

Breast cancer; estradiol; estrogen receptor; progesterone; progesterone receptor; PET imaging; tumour targeting; POSITRON-EMISSION-TOMOGRAPHY; HUMAN ESTROGEN-RECEPTOR; 11-BETA-SUBSTITUTED ESTRADIOL DERIVATIVES; TISSUE UPTAKE SELECTIVITY; SMALL ANIMAL PET; PROGESTERONE-RECEPTOR; IN-VIVO; HIGH-AFFINITY; BINDING-AFFINITY; RAT UTERUS;

D O I：

10.2174/092986713804806658

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The design and development of radiolabelled steroid derivatives has been an important area of research due to their well-known value in breast cancer targeting. The estrogen receptor (ER) and progesterone receptor (PR) are important biomarkers in the diagnosis, prognosis and follow-up of the therapeutic response of breast tumours. Thus, several radioligands based on estrogens and progestins have been proposed for targeted functional ER imaging. The aim of this review is to survey and analyze the developments in this field, which have led to the design of a number of PET steroid-based imaging agents, a few of which seem to be promising as radiopharmaceuticals for detection of ER-positive breast tumours.

引用

页码：222 / 245

页数：24

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