RETRACTED: The Oncolytic Virus in Cancer Diagnosis and Treatment (Retracted Article)

被引：74

作者：

Cao, Guo-dong ^{[1
]}

He, Xiao-bo ^{[1
]}

Sun, Qiang ^{[2
]}

Chen, Sihan ^{[1
]}

Wan, Ke ^{[3
]}

Xu, Xin ^{[1
]}

Feng, Xudong ^{[4
]}

Li, Peng-ping ^{[5
]}

Chen, Bo ^{[1
]}

Xiong, Mao-ming ^{[1
]}

机构：

[1] Anhui Med Univ, Affiliated Hosp 1, Dept Gen Surg, Hefei, Peoples R China

[2] Xuzhou Med Univ, Inst Canc, Jiangsu Key Lab Biol Canc, Xuzhou, Jiangsu, Peoples R China

[3] Anhui Med Univ, Dept Oncol, Hefei, Peoples R China

[4] Zhejiang Univ, Dept Infect Dis, Hangzhou, Peoples R China

[5] First Peoples Hosp Xiaoshan Dist, Dept Gen Surg, Hangzhou, Peoples R China

来源：

FRONTIERS IN ONCOLOGY | 2020年 / 10卷

关键词：

cancer; oncolytic virus; application; review; diagnosis; HERPES-SIMPLEX-VIRUS; SYNERGISTIC ANTITUMOR EFFICACY; RETROVIRAL REPLICATING VECTOR; VACCINIA VIRUS; IONIZING-RADIATION; MEASLES-VIRUS; NEUTRALIZING ANTIBODIES; CHECKPOINT BLOCKADE; VIRAL REPLICATION; SYSTEMIC DELIVERY;

D O I：

10.3389/fonc.2020.01786

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer has always been an enormous threat to human health and survival. Surgery, radiotherapy, and chemotherapy could improve the survival of cancer patients, but most patients with advanced cancer usually have a poor survival or could not afford the high cost of chemotherapy. The emergence of oncolytic viruses provided a new strategy for us to alleviate or even cure malignant tumors. An oncolytic virus can be described as a genetically engineered or naturally existing virus that can selectively replicate in cancer cells and then kill them without damaging the healthy cells. There have been many kinds of oncolytic viruses, such as herpes simplex virus, adenovirus, and Coxsackievirus. Moreover, they have different clinical applications in cancer treatment. This review focused on the clinical application of oncolytic virus and predicted the prospect by analyzing the advantages and disadvantages of oncolytic virotherapy.

引用

页数：12

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