Advances in the Field of Tissue Engineering and Regenerative Medicine: State of the Art and Regulatory Issues

被引：10

作者：

Gonzalez-Andrades, M. ^{[1
]}

Garzon, I. ^{[1
]}

Alaminos, M. ^{[1
]}

Campos, A. ^{[1
]}

Prosper, F. ^{[2
]}

Orive, G. ^{[3
,4
,5
]}

Anitua, E. ^{[5
]}

机构：

[1] Univ Granada, Sch Med, Dept Histol, Granada, Spain

[2] Univ Navarra, Univ Navarra Clin, Serv Hematol, Vitoria, Spain

[3] Univ Basque Country, Sch Pharm, Lab Pharmaceut, NanoBioCel Grp, Vitoria, Spain

[4] CIBER BBN, Networking Biomed Res Ctr Bioengn Biomat & Nanome, Vitoria, Spain

[5] Biotechnol Inst BTI, Vitoria 01007, Alava, Spain

来源：

JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING | 2013年 / 3卷 / 03期

关键词：

Tissue Engineering; Extracellular Matrix; Stem Cells; Morphogens; Growth Factors; MESENCHYMAL STEM-CELLS; GROWTH-FACTOR DELIVERY; IN-VITRO; OSTEOGENIC PROTEIN-1; EXTRACELLULAR-MATRIX; BIOLOGIC SCAFFOLDS; CONTROLLED-RELEASE; BONE-FORMATION; DRUG-DELIVERY; HYDROGELS;

D O I：

10.1166/jbt.2013.1089

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Tissue engineering applies the principles of engineering, medicine and life sciences to the generation of biological substitutes (artificial tissues, bioengineered tissues or tissue constructs) with the aim of restoring, maintaining, or improving tissue function. A complex regulatory frame controls the clinical application and commercialization of bioengineered tissues. In this review, we highlight the state of the art and recent advances on the three main components that are used to build artificial tissues, including cells-especially adult stem cells-, extracellular matrices and morphogens or molecular signals. In particular, we discuss the limitations and challenges of the field and the different causes that may justify this limited situation.

引用

页码：245 / 260

页数：16

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