Spreading Ischemia After Aneurysmal Subarachnoid Hemorrhage

被引：39

作者：

Dreier, Jens P. ^{[1
,2
,3
]}

Drenckhahn, Christoph ^{[1
,2
]}

Woitzik, Johannes ^{[1
,4
]}

Major, Sebastian ^{[1
,2
,3
]}

Offenhauser, Nikolas ^{[1
,3
]}

Weber-Carstens, Steffen ^{[5
]}

Wolf, Stefan ^{[4
]}

Strong, Anthony J. ^{[6
]}

Vajkoczy, Peter ^{[1
,4
]}

Hartings, Jed A. ^{[7
]}

机构：

[1] Charite Univ Med Berlin, Ctr Stroke Res Berlin, Campus Charite Mitte, Charitepl 1, D-10117 Berlin, Germany

[2] Charite Univ Med Berlin, Dept Neurol, D-10117 Berlin, Germany

[3] Charite Univ Med Berlin, Dept Expt Neurol, D-10117 Berlin, Germany

[4] Charite Univ Med Berlin, Dept Neurosurg, D-10117 Berlin, Germany

[5] Charite Univ Med Berlin, Dept Anesthesiol, D-10117 Berlin, Germany

[6] Kings Coll London, Dept Clin Neurosci, London, England

[7] Univ Cincinnati, Dept Neurosurg, Cincinnati, OH USA

来源：

CEREBRAL VASOSPASM: NEUROVASCULAR EVENTS AFTER SUBARACHNOID HEMORRHAGE | 2013年 / 115卷

关键词：

Aneurysmal subarachnoid hemorrhage; Spreading depression; Delayed cerebral ischemia; HUMAN CEREBRAL-CORTEX; PERIINFARCT DEPOLARIZATIONS; NEUROLOGICAL DEFICITS; BLOOD-FLOW; DC SHIFTS; DEPRESSION; BRAIN; RAT; DAMAGE; PERFUSION;

D O I：

10.1007/978-3-7091-1192-5_26

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Spreading depolarization (SD) is a wave of mass neuronal and glial depolarization associated with net influx of cations and water. Prolonged SDs facilitate neuronal death. SD induces tone alterations in cerebral resistance arterioles, leading to either transient hyperperfusion (physiological neurovascular coupling) in healthy tissue or hypoperfusion (inverse neurovascular coupling = spreading ischemia) in tissue at risk for progressive damage. Spreading ischemia has been shown experimentally in an animal model replicating the conditions present following aneurysmal subarachnoid hemorrhage (aSAH), in animal models of the ischemic core and penumbra following middle cerebral artery occlusion, and in patients with aSAH. In animals, spreading ischemia produced widespread cortical necrosis. In patients, spreading ischemia occurred in temporal correlation with ischemic lesion development early and late after aSAH. We briefly review important features of SD and spreading ischemia following aSAH.

引用

页码：125 / +

页数：3

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