Polydimethylsiloxane/nano calcium phosphate composite tracheal stents: Mechanical and physiological properties

被引：6
作者：
Demetrio, Ketner Bendo [1 ]
Giotti Cioato, Marta Justina [2 ]
Moreschi, Alexandre [2 ]
Oliveira, Guilherme Augusto [2 ]
Lorenzi, William [2 ]
de Oliveira, Francine Hehn [2 ]
de Macedo Neto, Amarilio Vieira [2 ]
Stefani Sanches, Paulo Roberto [2 ]
Xavier, Rogerio Gastal [2 ]
Loureiro dos Santos, Luis Alberto [3 ]
机构：
[1] UNESC Univ South Santa Catarina, Postgrad Program Sci & Engn Mat, PPGCEM, Criciuma, SC, Brazil
[2] HCPA, Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande do Sul, UFRGS, Dept Mat, LABIOMAT,Lab Biomat, Porto Alegre, RS, Brazil
来源：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS | 2019年 / 107卷 / 03期
关键词：
polydimethylsiloxane; calcium phosphate; nanohydroxyapatite; in vivo test; tracheal stent; HYDROXYAPATITE; BIOCOMPATIBILITY; HYDROLYSIS;
D O I：
10.1002/jbm.b.34145
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In this study, we report the production and characterization of tracheal stents composed of polydimethylsiloxane/nanostructured calcium phosphate composites obtained by reactive synthesis. Tracheal stents were produced by transfer molding, and in vivo tests were carried out. PDMS was combined with H3PO4 and Ca(OH)(2) via an in situ reaction to obtain nanoparticles of calcium phosphate dispersed within the polymeric matrix. The incorporation of bioactive inorganic substances, such as calcium phosphates, improved biological properties, and the in situ reaction allowed tight coupling of particles to the matrix. Results showed the presence of the nanoparticles of DCPA and CDHA. The porosity generated during mixing decreased the tensile strength and tear properties. Composites presented higher values of cell viability compared with those for PDMS. In vivo tests indicated the presence of inflammatory tissue 30 days after implantation in both cases. Thus, the present biomaterial shows potential for application in tracheal disease, however further evaluation is needed. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2018. (c) 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 545-553, 2019.
引用
收藏
页码：545 / 553
页数：9
相关论文
共 32 条
[1]   Modification of polysiloxane polymers for biomedical applications: a review [J].
Abbasi, F ;
Mirzadeh, H ;
Katbab, AA .
POLYMER INTERNATIONAL, 2001, 50 (12) :1279-1287
[2]  
[Anonymous], 1992, 109935 ISO
[3]   Nanostructured hydroxyapatite/polydimethylsiloxane composites obtained by reactive synthesis [J].
Bareiro Ferreira, Oscar Jacinto ;
Demetrio, Ketner Bendo ;
Loureiro dos Santos, Luis Alberto .
COMPOSITES PART B-ENGINEERING, 2017, 121 :152-161
[4]   Tetraethylorthosilicate (TEOS) applied in the surface modification of hydroxyapatite to develop polydimethylsiloxane/hydroxyapatite composites [J].
Bareiro, O. ;
Santos, L. A. .
COLLOIDS AND SURFACES B-BIOINTERFACES, 2014, 115 :400-405
[5]  
Berzina-Cimdina L, 2012, INFRARED SPECTROSCOPY - MATERIALS SCIENCE, ENGINEERING AND TECHNOLOGY, P123
[6]   On Studying the Interaction Between Different Stent Models and Rabbit Tracheal Tissue: Numerical, Endoscopic and Histological Comparison [J].
Chaure, J. ;
Serrano, C. ;
Fernandez-Parra, R. ;
Pena, E. ;
Lostale, F. ;
De Gregorio, M. A. ;
Martinez, M. A. ;
Malve, M. .
ANNALS OF BIOMEDICAL ENGINEERING, 2016, 44 (02) :368-381
[7]   Amorphous calcium (ortho)phosphates [J].
Dorozhkin, Sergey V. .
ACTA BIOMATERIALIA, 2010, 6 (12) :4457-4475
[8]   Calcium Orthophosphates in Nature, Biology and Medicine [J].
Dorozhkin, Sergey V. .
MATERIALS, 2009, 2 (02) :399-498
[9]  
Driessens FCM., 1998, BIOCERAMICS, V84, P77
[10]   Interaction of some essential amino acids with synthesized poorly crystalline hydroxyapatite [J].
El Rhilassi, A. ;
Mourabet, M. ;
Bennani-Ziatni, M. ;
El Hamri, R. ;
Taitai, A. .
JOURNAL OF SAUDI CHEMICAL SOCIETY, 2016, 20 :S632-S640
1234