Psychological factors substantially contribute to biological aging: evidence from the aging rate in Chinese older adults

被引：0

作者：

Galkin, Fedor ^{[1
]}

Kochetov, Kirill ^{[1
]}

Koldasbayeva, Diana ^{[1
]}

Faria, Manuel ^{[2
]}

Fung, Helene H. ^{[3
]}

Chen, Amber X. ^{[3
]}

Zhavoronkov, Alex ^{[1
,4
,5
]}

机构：

[1] Deep Longev Ltd, Hong Kong, Peoples R China

[2] Stanford Univ, Dept Psychol, Stanford, CA 94305 USA

[3] Chinese Univ Hong Kong, Dept Psychol, Hong Kong, Peoples R China

[4] Insilico Med, Hong Kong, Peoples R China

[5] Buck Inst Res Aging, Novato, CA 94945 USA

来源：

AGING-US | 2022年 / 14卷 / 18期

关键词：

psychological aging; lifespan psychology; aging clocks; longevity; NEURAL-NETWORKS; LIFE; HEALTH; IDENTIFICATION; BIOMARKER; EDUCATION; ONSET; DIET;

D O I：

暂无

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have developed a deep learning aging clock using blood test data from the China Health and Retirement Longitudinal Study, which has a mean absolute error of 5.68 years. We used the aging clock to demonstrate the connection between the physical and psychological aspects of aging. The clock detects accelerated aging in people with heart, liver, and lung conditions. We demonstrate that psychological factors, such as feeling unhappy or being lonely, add up to 1.65 years to one's biological age, and the aggregate effect exceeds the effects of biological sex, living area, marital status, and smoking status. We conclude that the psychological component should not be ignored in aging studies due to its significant impact on biological age.

引用

页码：7206 / 7222

页数：17

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