PrP genotype in Sarda breed sheep and its relevance to scrapie

被引：59

作者：

Vaccari, G

Petraroli, R

Agrimi, U

Eleni, C

Perfetti, MG

Di Bari, MA

Morelli, L

Ligios, C

Busani, L

Nonno, R

Di Guardo, G

机构：

[1] Ist Zooprofilatt Sperimentale Reg Lazio & Toscana, I-00178 Rome, Italy

[2] Appl Biosyst Inc, Rome, Italy

[3] Ist Super Sanita, Lab Vet Med, I-00161 Rome, Italy

[4] Ist Zooprofilatt Sperimentale Sardegna, Sassari, Italy

来源：

ARCHIVES OF VIROLOGY | 2001年 / 146卷 / 10期

关键词：

D O I：

10.1007/s007050170050

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several PrP gene polymorphisms modulate sheep scrapie susceptibility. Recently, an increase of scrapie outbreaks has been reported in Italy. A vaccine containing sheep brain homogenate was used in most of the outbreaks. We investigated PrP gene polymorphisms in scrapie-affected and clinically healthy Sarda breed sheep from a flock exposed to the aforementioned vaccine, and in affected Sarda sheep from unexposed flocks. All affected animals were (Gln/Gln)(171) homozygous. Moreover, we observed no variation for Ala(136) and a new polymorphism (Lys to Asn) at codon 176. Our findings confirm the correlation between scrapie and (Gln/Gln)(171) in breeds with no variation for Ala(136).

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页码：2029 / 2037

页数：9

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