Liver autophagy: physiology and pathology

被引：52

作者：

Komatsu, Masaaki ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Med Sci, Prot Metab Project, Setagaya Ku, Tokyo 1568506, Japan

来源：

JOURNAL OF BIOCHEMISTRY | 2012年 / 152卷 / 01期

关键词：

Atg; autophagy; hepatic tumour; liver; p62; TRANSCRIPTION FACTOR NRF2; ISOLATED RAT HEPATOCYTES; SELECTIVE AUTOPHAGY; TUMOR-SUPPRESSOR; HEPATOCELLULAR-CARCINOMA; ENDOPLASMIC-RETICULUM; PROTEIN-DEGRADATION; CONJUGATION SYSTEM; REGULATE AUTOPHAGY; LC3; LIPIDATION;

D O I：

10.1093/jb/mvs059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy has long been thought of as a bulk degradation system in which cytoplasmic components are sequestered by double-membrane structures called autophagosomes, and the contents are then degraded after autophagosomes fuse with lysosomes. Genetic experiments in yeast identified a set of Autophagy-related (ATG) genes that are essential for autophagy. We have since elucidated many of the molecular underpinnings of autophagy and the physiologic roles of these processes in various systems. This review summarizes the physiologic roles of autophagy with a particular focus on liver autophagy based on analyses of knockout mice lacking Atg genes.

引用

页码：5 / 15

页数：11

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