Macrocyclic bis-quinolizidine alkaloids from Xestospongia muta

被引：14

作者：

Duong Thi Dung ^{[1
,2
]}

Dan Thi Thuy Hang ^{[1
]}

Pham Hai Yen ^{[1
]}

Tran Hong Quang ^{[1
]}

Nguyen Xuan Nhiem ^{[1
]}

Bui Huu Tai ^{[1
,2
]}

Chau Van Minh ^{[1
]}

Kim, Youn-Chul ^{[3
]}

Kim, Dong Cheol ^{[3
]}

Oh, Hyuncheol ^{[3
]}

Phan Van Kiem ^{[1
,2
]}

机构：

[1] VAST, Inst Marine Biochem, Hanoi, Vietnam

[2] Grad Univ Sci & Technol, VAST, Hanoi, Vietnam

[3] Wonkwang Univ, Coll Pharm, Iksan, South Korea

来源：

NATURAL PRODUCT RESEARCH | 2019年 / 33卷 / 03期

关键词：

meso araguspongine C; bis quinolizidine alkaloid; cytotoxicity; Xestospongia muta; SPONGE; PETROSIN;

D O I：

10.1080/14786419.2018.1455043

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new stereoisomer Meso-araguspongine C together with nine reported macrocyclic bis-quinolizidine alkaloids araguspongines A, C, E, L, N-P, petrosin, and petrosin A were isolated from marine sponge Xestospongia muta. Stereochemistry of meso-araguspongine C (2) and araguspongines N-P (3-5) were established by their NMR data and conformational analyses. Both araguspongine C (1) and meso-araguspongine C (2) exhibited great cytotoxic activity towards HepG-2, HL-60, LU-1, MCF-7, and SK-Mel-2 human cancer cells (IC50 in the range of 0.43-1.02 mu M). At a concentration of 20 mu M, isolated compounds (1-10) also showed modest inhibitory effects (from 7.6 to 40.8%) on the NO production in LPS activated RAW264.7 macrophages. [GRAPHICS] .

引用

页码：400 / 406

页数：7

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