Anti-Trichomonas vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species

被引：31

作者：

Rocha, Tabitha Dahmer ^{[1
]}

Vieira, Patricia de Brum ^{[2
]}

Baggio Gnoatto, Simone Cristina ^{[1
]}

Tasca, Tiana ^{[2
]}

Gosmann, Grace ^{[1
]}

机构：

[1] Univ Fed Rio Grande do Sul, Lab Fitoquim & Sintese Organ, Dept Prod Materia Prima, Fac Farm, BR-90610000 Porto Alegre, RS, Brazil

[2] Univ Fed Rio Grande do Sul, Lab Pesquisa Parasitol, Dept Anal, Fac Farm, BR-90610000 Porto Alegre, RS, Brazil

来源：

PARASITOLOGY RESEARCH | 2012年 / 110卷 / 06期

关键词：

MEXICAN TRADITIONAL MEDICINE; ANTIGIARDIAL ACTIVITY; ADJUVANT; LEAVES;

D O I：

10.1007/s00436-011-2798-1

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Trichomonas vaginalis is a flagellated protozoan that causes trichomonosis, the most prevalent non-viral STD worldwide. The pathogen has been associated with serious health consequences including predisposition to cervical cancer and adverse pregnancy outcomes and infertility. It also acts as a co-factor in HIV transmission and acquisition. The 5-nitroimidazole drugs are used in the treatment, however, treatment noncompliance is observed, and a growing number of T. vaginalis isolates resistant to the drugs have been related. Saponins are natural products possessing many biological activities such as antiprotozoan activity. The aim of this study was to evaluate the anti-T. vaginalis activity of saponins from Quillaja, Passiflora, and Ilex species. Saponins from Passiflora alata and Quillaja saponaria presented the best anti-T. vaginalis activity (MIC = 0.025%). In addition, all samples induced erythrocyte lysis and LDH release. As far as we know, this is the first report demonstrating the potential anti-T. vaginalis activity of these saponins.

引用

页码：2551 / 2556

页数：6

共 32 条

[1] Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole alkaloids isolated from the leaves of Murraya koenigii growing in Nigeria [J].