CTCF: from insulators to alternative splicing regulation

被引：17
作者：
Kornblihtt, Alberto R. [1 ]
机构：
[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Lab Fisiol & Biol Mol, Dept Fisiol Biol Mol & Celular,IFIBYNE CONICET, Buenos Aires, DF, Argentina
来源：
CELL RESEARCH | 2012年 / 22卷 / 03期
关键词：
RNA-POLYMERASE-II; DNA METHYLATION; CHROMATIN; TRANSCRIPTION; ELONGATION; CELLS; EXONS;
D O I：
10.1038/cr.2012.22
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The zinc-finger DNA-binding protein CTCF has been known for being a constituent of insulators. A recent paper in Nature reports an unforeseen intragenic role for CTCF that links DNA methylation with alternative splicing. By binding to its target DNA site placed within an alternative exon, CTCF creates a roadblock to transcriptional elongation that favors inclusion of the exon into mature mRNA. DNA methylation prevents CTCF binding, which releases pol II transient blockage and promotes exon exclusion.
引用
收藏
页码：450 / 452
页数：3
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