Analysis of Genome-wide Association Study-linked Loci in Parkinson's Disease of Mainland China

被引：40

作者：

Liu, Jun ^{[1
,2
]}

Xiao, Qin ^{[1
,2
]}

Wang, Ying ^{[1
,2
,3
,4
]}

Xu, Zhi-Min ^{[1
,2
]}

Wang, Ying ^{[1
,2
,3
,4
]}

Yang, Qiong ^{[1
,2
]}

Wang, Gang ^{[1
,2
]}

Tan, Yu-Yan ^{[1
,2
]}

Ma, Jian-Fang ^{[1
,2
]}

Zhang, Jin ^{[1
,2
]}

Huang, Wei ^{[1
,2
,3
,4
]}

Chen, Sheng-Di ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Neurol, Shanghai 200030, Peoples R China

[2] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Inst Neurol, Shanghai 200030, Peoples R China

[3] Chinese Natl Human Genome Ctr, Dept Genet, Shanghai MOST Key Lab Hlth & Dis Genom, Shanghai 201203, Peoples R China

[4] Shanghai Acad Sci & Technol, Shanghai, Peoples R China

来源：

MOVEMENT DISORDERS | 2013年 / 28卷 / 13期

关键词：

Parkinson's disease; single nucleotide polymorphism; SNCA; BST1; POPULATION; VARIANTS; MUTATION; GENETICS; SNCA;

D O I：

10.1002/mds.25599

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

BackgroundGenome-wide association studies (GWAS) have identified numerous single-nucleotide polymorphisms (SNPs) that can modulate the risk of developing Parkinson's disease (PD). MethodsWe investigated the association of previously identified loci in a Mainland Chinese population to identify a possible ethnic-specific effect with GWAS analysis. Seventeen SNPs were genotyped from those loci using case-control methodology to analyze a total of 1,737 individuals. ResultsStrong evidence of an association for reference SNP 894278 (rs894278) and rs11931074 on 4q22 throughout the synuclein (SNCA) region was observed in our study. The SNP rs894278 confers risk via a dominant model and an additive model, whereas the minor allele G of rs11931074 reduces the risk of PD progression. The minor allele frequency of rs11724635 produced weaker signals for PD, but this was not replicated in the genotype after adjusting for age and sex. ConclusionsThis study yields new clues about GWAS-linked data in patients with PD from Mainland China. (c) 2013 International Parkinson and Movement Disorder Society

引用

页码：1892 / 1895

页数：4

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