Synthesis of 2-Tetrazolylmethyl-2,3,4,9-tetrahydro-1H-β-carbolines by a One-Pot Ugi-Azide/Pictet-Spengler Process

被引：27
|
作者：
Cardenas-Galindo, Luis E. [1 ]
Islas-Jacome, Alejandro [1 ]
Alvarez-Rodriguez, Nancy V. [1 ]
El Kaim, Laurent [2 ]
Gamez-Montano, Rocio [1 ]
机构：
[1] Univ Guanajuato, Div Ciencias Nat & Exactas, Dept Quim, Guanajuato 36050, Mexico
[2] Ecole Natl Super Tech Avancees, Lab Chim & Proc, Ecole Polytech ENSTA CNRS UMR 7652, F-75015 Paris, France
来源：
SYNTHESIS-STUTTGART | 2014年 / 46卷 / 01期
关键词：
tetrazoles; tetrahydro-1H--carbolines; MCR; Ugi-azide; Pictet-Spengler; TETRAHYDRO-BETA-CARBOLINES; PHARMACODYNAMIC HYBRIDS; SPECTRAL PROPERTIES; CONCISE ROUTE; DERIVATIVES; CYCLIZATION; ALKALOIDS; REARRANGEMENT; CONDENSATION; ISOCYANIDES;
D O I：
10.1055/s-0033-1340051
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel 2-tetrazolylmethyl-2,3,4,9-tetrahydro-1H--carbolines were prepared in good to excellent overall yields by an efficient MW-assisted one-pot Ugi-azide/Pictet-Spengler process. This work describes the first synthesis of compounds including both 1,5-disubstituted 1H-tetrazole and 2,3,4,9-tetrahydro-1H--carboline heterocyclic systems.
引用
收藏
页码：49 / 56
页数：8
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