A resource of mapped human bacterial artificial chromosome clones

被引：12

作者：

Cheung, VG ^{[1
]}

Dalrymple, HL

Narasimhan, S

Watts, J

Schuler, G

Raap, AK

Morley, M

Bruzel, A

机构：

[1] Univ Penn, Childrens Hosp, Dept Pediat, Philadelphia, PA 19104 USA

[2] NIH, Natl Ctr Biotechnol Informat, Bethesda, MD 20894 USA

[3] Leiden Univ, Med Ctr, Dept Mol Cell Biol, Leiden, Netherlands

来源：

GENOME RESEARCH | 1999年 / 9卷 / 10期

关键词：

D O I：

10.1101/gr.9.10.989

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To date, despite the increasing number of genomic tools, there is no repository of ordered human BAC clones that covers entire chromosomes. This project presents a resource of mapped large DNA fragments that span eight human chromosomes at similar to 1-Mb resolution. These DNA fragments are bacterial artificial chromosome (BAC) clones anchored to sequence tagged site (STS) markers. This clone collection, which currently contains 759 mapped clones, is useful in a wide range of applications from microarray-based gene mapping to identification of chromosomal mutations. In addition to the clones themselves, we describe a database, GenMapDB (http://genomics.med.upenn.edu/genmapdb), that contains information about each clone in our collection.

引用

页码：989 / 993

页数：5

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