Pinacidil relaxing effect on phenylephrine-precontracted guinea pig aorta was abolished by pretreatment with 17-β-estradiol

被引：1

作者：

Kocic, I. ^{[1
,2
]}

Gruchala-Niedoszytko, M. ^{[1
]}

机构：

[1] Dept Pharmacol, PL-80204 Gdansk, Poland

[2] Med Univ Gdansk, Dept Clin Pharmacol & Toxicol, Inter Fac Inst Maritimal & Trop Med, PL-81519 Gdynia, Poland

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2009年 / 133卷 / 01期

关键词：

Pinacidil; Estrogen; Potassium channels; Guinea pig heart; Aorta; Smooth muscle; GENDER-DIFFERENCES; HEART; RAT; SEX; CHANNELS; ESTROGEN;

D O I：

10.1016/j.ijcard.2007.08.117

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In this paper we have shown that estrogen selectively diminishes relaxing effects of pinacidil, but not other activators of ATP-sensitive K(+) channels, on guinea pig aortic rings precontracted by phenylephrine. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：116 / 118

页数：3

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