Aging, opioid-receptor agonists and antagonists, and the vestibulosympathetic reflex in humans

被引:4
作者
Ray, CA
Monahan, KD
机构
[1] Penn State Univ, Milton S Hershey Med Ctr, Coll Med, Gen Clin Res Ctr,Dept Med,Div Cardiol, Hershey, PA 17033 USA
[2] Penn State Univ, Coll Med, Gen Clin Res Ctr, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA
关键词
autonomic nervous system; blood pressure regulation; otolith organs; naloxone; codeine;
D O I
10.1152/japplphysiol.00528.2003
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Animal studies indicate that opioids inhibit the firing rate of vestibular neurons, which are important in mediating the vestibulosympathetic reflex. Furthermore, this inhibition appears to be greater in more mature rats. In the present study, we tested the hypotheses that opioids inhibit the vestibulosympathetic reflex in humans and that endogenous opioids contribute to the age-related impairment of the vestibulosympathetic reflex. These hypotheses were tested by measuring muscle sympathetic nerve activity ( MSNA), arterial blood pressure, and heart rate responses to otolith organ engagement during head-down rotation (HDR) in young (24 +/- 2 yr old) and older (63 +/- 2 yr) subjects before and after administration of either an opioid-receptor antagonist ( 16 mg naloxone in 9 young and 8 older subjects) or an opioid-receptor agonist ( 60 mg codeine in 7 young and 7 older subjects). Naloxone did not augment the reflex increase in MSNA during HDR in young (Delta7 +/- 2 vs. Delta4 +/- 2 bursts/min and Delta81 +/- 23 vs. Delta60 +/- 24% change in burst frequency and total MSNA before and after naloxone, respectively) or older subjects (Delta2 +/- 2 vs. Delta1 +/- 2 burst/min and Delta8 +/- 7 vs. Delta8 +/- 9% before and after naloxone). Similarly, codeine did not attenuate the increase in MSNA during HDR in young (Delta8 +/- 1 vs. Delta7 +/- 2 bursts/min and Delta53 +/- 4 vs. Delta64 +/- 16% before and after codeine) or older subjects (Delta6 +/- 4 vs. Delta3 +/- 3 bursts/min and Delta38 +/- 21 vs. Delta33 +/- 20%). Mean arterial blood pressure and heart rate responses to HDR were not altered by either naloxone or codeine. These data do not provide experimental support for the concept that opioids modulate the vestibulosympathetic reflex in humans. Moreover, endogenous opioids do not appear to contribute the age-associated impairment of the vestibulosympathetic reflex.
引用
收藏
页码:1761 / 1766
页数:6
相关论文
共 40 条
[1]   HUMAN PHARMACOKINETIC STUDY OF IMMEDIATE-RELEASE (CODEINE PHOSPHATE) AND SUSTAINED-RELEASE (CODEINE CONTIN) CODEINE [J].
BAND, CI ;
BAND, PR ;
DESCHAMPS, M ;
BESNER, JG ;
COLDMAN, AJ .
JOURNAL OF CLINICAL PHARMACOLOGY, 1994, 34 (09) :938-943
[2]   THE NUCLEI OF ORIGIN OF BRAIN-STEM ENKEPHALIN AND CHOLECYSTOKININ PROJECTIONS TO THE SPINAL TRIGEMINAL NUCLEUS OF THE RAT [J].
BEITZ, AJ ;
CLEMENTS, JR ;
ECKLUND, LJ ;
MULLETT, MM .
NEUROSCIENCE, 1987, 20 (02) :409-425
[3]   AGE-ASSOCIATED INCREASE IN RAT CARDIAC OPIOID PRODUCTION [J].
BOLUYT, MO ;
YOUNES, A ;
CAFFREY, JL ;
ONEILL, L ;
BARRON, BA ;
CROW, MT ;
LAKATTA, EG .
AMERICAN JOURNAL OF PHYSIOLOGY, 1993, 265 (01) :H212-H218
[4]   beta-endorphin concentration in peripheral blood mononuclear cells of elderly depressed patients - Effects of phosphatidylserine therapy [J].
Brambilla, F ;
Maggioni, M ;
Panerai, AE ;
Sacerdote, P ;
Cenacchi, T .
NEUROPSYCHOBIOLOGY, 1996, 34 (01) :18-21
[5]   NEUROTRANSMITTER AND PEPTIDE RECEPTORS ON MEDIAL VESTIBULAR NUCLEUS NEURONS [J].
CARPENTER, DO ;
HORI, N .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1992, 656 :668-686
[6]   Muscle pain perception and sympathetic nerve activity to exercise during opioid modulation [J].
Cook, DB ;
O'Connor, PJ ;
Ray, CA .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2000, 279 (05) :R1565-R1573
[7]  
Cugini P, 1992, Clin Auton Res, V2, P113, DOI 10.1007/BF01819666
[8]  
DOBA N, 1974, CIRC RES, V34, P9, DOI 10.1161/01.RES.34.1.9
[9]   The opioid receptor antagonist, naloxone, enhances ocular motor compensation in guinea pig following peripheral vestibular deafferentation [J].
Dutia, MB ;
Gilchrist, DPD ;
Sansom, AJ ;
Smith, PF ;
Darlington, CL .
EXPERIMENTAL NEUROLOGY, 1996, 141 (01) :141-144
[10]  
Engstrom H, 1977, Adv Otorhinolaryngol, V22, P93