A triphenylphosphine coordinated Cu(I) Fenton-like agent with ferrocene moieties for enhanced chemodynamic therapy

被引：4

作者：

Zhong, Jingjing ^{[1
]}

Hong, Zhaoguo ^{[1
]}

Huang, Sudi ^{[1
]}

Zhong, Qiongqiong ^{[1
]}

Zhang, Liangliang ^{[1
]}

Zhao, Shulin ^{[1
]}

Liang, Hong ^{[1
]}

Huang, Fu-Ping ^{[1
]}

机构：

[1] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

来源：

DALTON TRANSACTIONS | 2022年 / 51卷 / 47期

基金：

中国国家自然科学基金;

关键词：

NANOPARTICLES; GROWTH;

D O I：

10.1039/d2dt03088h

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A triphenylphosphine coordinated Cu(i) complex of Fc-OD-Cu was rationally designed for chemodynamic therapy (CDT) of cancer. The complex was capable of generating a highly toxic hydroxyl radical (OH) via a Fenton-like reaction induced by Cu(i) moieties and simultaneously mediated by ferrocene moieties. As a result, the CDT efficiency of Fc-OD-Cu is higher than that of Ba-OD-Cu (without ferrocene moieties) and Fc-OD (without Cu(i) moieties).

引用

页码：18054 / 18058

页数：5

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