Simultaneous optimization of feeding rate and operation parameters for fed-batch fermentation processes

被引：33

作者：

Wang, FS ^{[1
]}

Cheng, WM ^{[1
]}

机构：

[1] Natl Chung Cheng Univ, Dept Chem Engn, Chiayi 62107, Taiwan

来源：

BIOTECHNOLOGY PROGRESS | 1999年 / 15卷 / 05期

关键词：

D O I：

10.1021/bp990088o

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

An efficient method is introduced for simultaneously determining optimal polices of feeding rate and operation parameters for a fermentation process. Such an optimization problem is converted into the finite dimensional optimization problem using the control parametrization technique. The hybrid differential evolution is introduced to solve the converted problem. The optimal production rate obtained by the simultaneous optimization approach could be significantly improved with comparison to a simplified optimization problem, which is considered the optimal feed control only, as observed from the simulation results.

引用

页码：949 / 952

页数：4

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