Postoperative 5-FU based Radiochemotherapy in Rectal Cancer: Retrospective Long Term Results and Prognostic Factors of a Pooled Analysis on 1,338 Patients

被引：0

作者：

Genovesi, Domenico ^{[1
]}

Myerson, Robert J. ^{[2
]}

Cefaro, Giampiero Ausili ^{[1
]}

Vinciguerra, Annamaria ^{[1
]}

Augurio, Antonietta ^{[1
]}

Trignani, Marianna ^{[1
]}

Di Tommaso, Monica ^{[1
]}

Nuzzo, Marianna ^{[1
]}

Lupattelli, Marco ^{[3
]}

Aristei, Cynthia ^{[3
]}

Bellavita, Rita ^{[3
]}

Scandolaro, Luciano ^{[4
]}

Cosentino, Dorian ^{[4
]}

Pani, Giuseppe ^{[5
]}

Ziccarelli, Luigi ^{[6
]}

Gambacorta, Maria A. ^{[7
]}

Barba, Maria C. ^{[7
]}

Maranzano, Ernesto ^{[8
]}

Trippa, Fabio ^{[8
]}

Sciacero, Piera ^{[9
]}

Niespolo, Rita ^{[10
]}

Leonardi, Cristina ^{[11
]}

Iannone, Tiziana ^{[12
]}

Rosetto, Maria Elena ^{[13
]}

Fusco, Vincenzo ^{[14
]}

Sanpaolo, Piero ^{[14
]}

Melano, Antonella ^{[15
]}

Valvo, Francesca ^{[16
]}

Capirci, Carlo ^{[17
]}

De Paoli, Antonino ^{[18
]}

Di Nicola, Marta ^{[19
]}

Mantello, Giovanna ^{[20
]}

Valentini, Vincenzo ^{[7
]}

机构：

[1] Univ G DAnnunzio, Dept Radiotherapy, I-66100 Chieti, Italy

[2] Washington Univ, Dept Radiat Oncol, St Louis, MO USA

[3] Dept Radiotherapy, Perugia, Italy

[4] Dept Radiotherapy, Como, Italy

[5] Dept Radiotherapy, Trento, Italy

[6] Dept Radiotherapy, Cosenza, Italy

[7] Univ Cattolica Sacro Cuore, Dept Radiotherapy, Rome, Italy

[8] Dept Radiotherapy, Terni, Italy

[9] Dept Radiotherapy, Ivrea, Italy

[10] Dept Radiotherapy, Monza, Italy

[11] European Inst Oncol, Dept Radiotherapy, Milan, Italy

[12] Dept Radiotherapy, Belluno, Italy

[13] Dept Radiotherapy, Viterbo, Italy

[14] CRO, Dept Radiotherapy, Rionero In Vulture, Italy

[15] Dept Radiotherapy, Cuneo, Italy

[16] Ist Nazl Tumori, Dept Radiotherapy, I-20133 Milan, Italy

[17] Dept Radiotherapy, Rovigo, Italy

[18] CRO, Dept Radiotherapy, Aviano, Italy

[19] Univ G DAnnunzio, Dept Biomed Sci, Lab Biostat, I-66100 Chieti, Italy

[20] Dept Radiotherapy, Ancona, Italy

来源：

ANTICANCER RESEARCH | 2013年 / 33卷 / 10期

关键词：

Rectal cancer; adjuvant therapy; staging; prognostic factors; ADJUVANT RADIATION-THERAPY; UICC STAGE-II; LOCAL RECURRENCE; PHASE-III; EUROPEAN-ORGANIZATION; COLORECTAL-CANCER; RADICAL SURGERY; DUKES B; RADIOTHERAPY; FLUOROURACIL;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To evaluate survival outcomes of patients in pStage II-III rectal cancer treated with adjuvant 5-fluorouracil-based radiochemotherapy and toretrospectively analyze the impact of prognostic variables on local control, metastasis-free survival and cause-specific survival. Patients and Methods: A total of 1,338 patients, treated between 1985-2005 for locally advanced rectal cancer, who underwent surgery and postoperative 5-fluorouracil-based chemoradiation, were selected. Results: The actuarial 5- and 10-year outcomes were: local control 87.0%-84.1%, disease-free survival 61.6%-52.1%, metastasis-free survival 72.0%-67.2%, cause-specific survival 70.4%-57.5%, and overall survival 63.8%-53.4%. Better outcomes were observed in patients with IIA, IIIA stage. Multivariate analyses showed that variables significantly affecting metastasis-free survival were pT4 and pN2, while for cancer-specific survival those variables were age >65 years, pT4, pN1, pN2, distal tumors and number of lymph nodes removed <= 12 Conclusion: This study confirmed that among stage II-III rectal cancer patients there are subgroups of patients with different clinical outcomes.

引用

页码：4557 / 4566

页数：10

共 7 条

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[6] Preoperative concomitant radiochemotherapy with a 5-fluorouracil plus folinic acid bolus in the combined treatment of locally advanced extraperitoneal rectal cancer:: A long-term analysis on 27 patients
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